{"id":223096,"date":"2025-10-08T15:09:39","date_gmt":"2025-10-08T20:09:39","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/10\/halo-hierarchical-causal-modeling-for-single-cell-multi-omics-data"},"modified":"2025-10-08T15:09:39","modified_gmt":"2025-10-08T20:09:39","slug":"halo-hierarchical-causal-modeling-for-single-cell-multi-omics-data","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/10\/halo-hierarchical-causal-modeling-for-single-cell-multi-omics-data","title":{"rendered":"HALO: hierarchical causal modeling for single cell multi-omics data"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/halo-hierarchical-causal-modeling-for-single-cell-multi-omics-data.jpg\"><\/a><\/p>\n<p>Chromatin accessibility dynamics causally influence changes in gene expression levels, but these fluctuations may not be directly coupled over time. Here, authors develop computational causal framework HALO, examining epigenetic plasticity and gene regulation dynamics in single-cell multi-omic data.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Chromatin accessibility dynamics causally influence changes in gene expression levels, but these fluctuations may not be directly coupled over time. Here, authors develop computational causal framework HALO, examining epigenetic plasticity and gene regulation dynamics in single-cell multi-omic data.<\/p>\n","protected":false},"author":661,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1523,412],"tags":[],"class_list":["post-223096","post","type-post","status-publish","format-standard","hentry","category-computing","category-genetics"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/223096","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/661"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=223096"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/223096\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=223096"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=223096"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=223096"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}