{"id":222995,"date":"2025-10-07T03:25:13","date_gmt":"2025-10-07T08:25:13","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/10\/synaptic-changes-in-the-brains-of-patients-with-frontotemporal-dementia-can-be-modeled-in-the-laboratory"},"modified":"2025-10-07T03:25:13","modified_gmt":"2025-10-07T08:25:13","slug":"synaptic-changes-in-the-brains-of-patients-with-frontotemporal-dementia-can-be-modeled-in-the-laboratory","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/10\/synaptic-changes-in-the-brains-of-patients-with-frontotemporal-dementia-can-be-modeled-in-the-laboratory","title":{"rendered":"Synaptic changes in the brains of patients with frontotemporal dementia can be modeled in the laboratory"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/synaptic-changes-in-the-brains-of-patients-with-frontotemporal-dementia-can-be-modeled-in-the-laboratory2.jpg\"><\/a><\/p>\n<p>Neurons produced from frontotemporal dementia patients\u2019 skin biopsies using modern stem cell technology recapitulate the synaptic loss and dysfunction detected in the patients\u2019 brains, a new study from the University of Eastern Finland shows.<\/p>\n<p>Frontotemporal dementia is a progressive neurodegenerative disease affecting the frontal and temporal lobes of the brain. The most common symptoms are <a href=\"https:\/\/medicalxpress.com\/tags\/behavioral+changes\/\" rel=\"tag\" class=\"\">behavioral changes<\/a>, difficulties in understanding or producing speech, problems in movement, and psychiatric symptoms.<\/p>\n<p>Often, <a href=\"https:\/\/medicalxpress.com\/tags\/frontotemporal+dementia\/\" rel=\"tag\" class=\"\">frontotemporal dementia<\/a> has no identified genetic cause, but especially in Finnish patients, hexanucleotide repeat expansion in the C9orf72 gene is a common genetic cause, present in about half of the familial cases and in 20% of the sporadic cases where there is no family history of the disease.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Neurons produced from frontotemporal dementia patients\u2019 skin biopsies using modern stem cell technology recapitulate the synaptic loss and dysfunction detected in the patients\u2019 brains, a new study from the University of Eastern Finland shows. Frontotemporal dementia is a progressive neurodegenerative disease affecting the frontal and temporal lobes of the brain. The most common symptoms are [\u2026]<\/p>\n","protected":false},"author":427,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412,47],"tags":[],"class_list":["post-222995","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/222995","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/427"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=222995"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/222995\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=222995"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=222995"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=222995"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}