{"id":222689,"date":"2025-09-30T04:35:55","date_gmt":"2025-09-30T09:35:55","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/09\/pa-915-molecule-shows-long-lasting-antidepressant-effects-without-common-side-effects-in-mice"},"modified":"2025-09-30T04:35:55","modified_gmt":"2025-09-30T09:35:55","slug":"pa-915-molecule-shows-long-lasting-antidepressant-effects-without-common-side-effects-in-mice","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/09\/pa-915-molecule-shows-long-lasting-antidepressant-effects-without-common-side-effects-in-mice","title":{"rendered":"PA-915 molecule shows long-lasting antidepressant effects without common side effects in mice"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/pa-915-molecule-shows-long-lasting-antidepressant-effects-without-common-side-effects-in-mice.jpg\"><\/a><\/p>\n<p>Depression and anxiety disorders are among the most widespread mental health disorders, with estimates suggesting that they affect around 264 million and 284 million people worldwide, respectively. Depression is a mood disorder characterized by persistent sadness and a loss of interest in everyday activities, while anxiety disorders are marked by high levels of nervousness, worry and fear, either in specific situations or generalized.<\/p>\n<p>Today, there are several <a href=\"https:\/\/medicalxpress.com\/tags\/treatment+options\/\" rel=\"tag\" class=\"\">treatment options<\/a> for both depression and <a href=\"https:\/\/medicalxpress.com\/tags\/anxiety+disorders\/\" rel=\"tag\" class=\"\">anxiety disorders<\/a>, including both pharmacological drugs and specific types of psychotherapy. Yet available therapeutic strategies are not effective for all affected individuals; thus, identifying alternative treatments could be highly advantageous.<\/p>\n<p>Researchers at the University of Osaka, Kobe University School of Medicine, Hamamatsu University School of Medicine and other institutes have recently developed a <a href=\"https:\/\/medicalxpress.com\/tags\/new+molecule\/\" rel=\"tag\" class=\"\">new molecule<\/a> called PA-915, which could hold some promise for the treatment of depression, anxiety and stress-related disorders. In a paper <a href=\"https:\/\/www.nature.com\/articles\/s41380-025-03209-4\" target=\"_blank\">published<\/a> in <i>Molecular Psychiatry<\/i>, they showed that the molecule suppressed both anxiety-like and depression-like behaviors in mice who were placed under high levels of stress.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Depression and anxiety disorders are among the most widespread mental health disorders, with estimates suggesting that they affect around 264 million and 284 million people worldwide, respectively. Depression is a mood disorder characterized by persistent sadness and a loss of interest in everyday activities, while anxiety disorders are marked by high levels of nervousness, worry [\u2026]<\/p>\n","protected":false},"author":427,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,47],"tags":[],"class_list":["post-222689","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/222689","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/427"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=222689"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/222689\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=222689"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=222689"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=222689"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}