{"id":222535,"date":"2025-09-26T08:07:36","date_gmt":"2025-09-26T13:07:36","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/09\/new-protein-interaction-map-sheds-light-on-how-brain-cell-communication-breaks-down-in-alzheimers-disease"},"modified":"2025-09-26T08:07:36","modified_gmt":"2025-09-26T13:07:36","slug":"new-protein-interaction-map-sheds-light-on-how-brain-cell-communication-breaks-down-in-alzheimers-disease","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/09\/new-protein-interaction-map-sheds-light-on-how-brain-cell-communication-breaks-down-in-alzheimers-disease","title":{"rendered":"New protein interaction map sheds light on how brain cell communication breaks down in Alzheimer\u2019s disease"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/new-protein-interaction-map-sheds-light-on-how-brain-cell-communication-breaks-down-in-alzheimers-disease.jpg\"><\/a><\/p>\n<p>A new study led by the Icahn School of Medicine at Mount Sinai offers one of the most comprehensive views yet of how brain cells interact in Alzheimer\u2019s disease, mapping protein networks that reveal communication failures and point to new therapeutic opportunities.<\/p>\n<p>Published online in <i>Cell<\/i>, the <a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(25)01031-1\" target=\"_blank\">study<\/a> analyzed <a href=\"https:\/\/medicalxpress.com\/tags\/protein+activity\/\" rel=\"tag\" class=\"\">protein activity<\/a> in brain tissue from nearly 200 individuals.<\/p>\n<p>The researchers discovered that disruptions in communication between neurons and supporting <a href=\"https:\/\/medicalxpress.com\/tags\/brain+cells\/\" rel=\"tag\" class=\"\">brain cells<\/a> called glia\u2014specifically astrocytes and microglia\u2014are closely linked to the progression of Alzheimer\u2019s disease. One protein in particular, called AHNAK, was identified as a top driver of these harmful interactions.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A new study led by the Icahn School of Medicine at Mount Sinai offers one of the most comprehensive views yet of how brain cells interact in Alzheimer\u2019s disease, mapping protein networks that reveal communication failures and point to new therapeutic opportunities. Published online in Cell, the study analyzed protein activity in brain tissue from [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,47],"tags":[],"class_list":["post-222535","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/222535","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=222535"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/222535\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=222535"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=222535"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=222535"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}