{"id":222465,"date":"2025-09-25T12:14:24","date_gmt":"2025-09-25T17:14:24","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/09\/breakthrough-gene-therapy-slows-huntingtons-disease-by-75"},"modified":"2025-09-25T12:14:24","modified_gmt":"2025-09-25T17:14:24","slug":"breakthrough-gene-therapy-slows-huntingtons-disease-by-75","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/09\/breakthrough-gene-therapy-slows-huntingtons-disease-by-75","title":{"rendered":"Breakthrough Gene Therapy Slows Huntington\u2019s Disease by 75%"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/breakthrough-gene-therapy-slows-huntingtons-disease-by-75.jpg\"><\/a><\/p>\n<p>Researchers in the United Kingdom say they have successfully trialed what could become the world\u2019s first gene therapy for <a href=\"https:\/\/en.wikipedia.org\/wiki\/Huntington%27s_disease\">Huntington\u2019s disease<\/a> \u2013 a fatal neurodegenerative disorder that is typically inherited.<\/p>\n<p>While the results of the <a href=\"https:\/\/www.sciencealert.com\/clinical-trials\" rel=\"nofollow\" target=\"_self\">clinical trial<\/a> are not yet formally published or peer reviewed, principal investigator and neuroscientist Ed Wild from University College London <a href=\"https:\/\/www.ucl.ac.uk\/news\/2025\/sep\/gene-therapy-appears-slow-huntingtons-disease-progression\">says<\/a> the gene therapy, called AMT-130, \u201cchanges everything.\u201d<\/p>\n<p>The highest dose can apparently slow disease progression by as much as 75 percent over three years. It also led to a significant reduction in a biomarker of neurodegeneration, found in cerebrospinal fluid, which usually increases with disease progression.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers in the United Kingdom say they have successfully trialed what could become the world\u2019s first gene therapy for Huntington\u2019s disease \u2013 a fatal neurodegenerative disorder that is typically inherited. While the results of the clinical trial are not yet formally published or peer reviewed, principal investigator and neuroscientist Ed Wild from University College London [\u2026]<\/p>\n","protected":false},"author":396,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,47],"tags":[],"class_list":["post-222465","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/222465","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/396"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=222465"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/222465\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=222465"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=222465"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=222465"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}