{"id":222429,"date":"2025-09-25T00:04:20","date_gmt":"2025-09-25T05:04:20","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/09\/enhanced-car-t-cells-emerge-from-genetic-screening"},"modified":"2025-09-25T00:04:20","modified_gmt":"2025-09-25T05:04:20","slug":"enhanced-car-t-cells-emerge-from-genetic-screening","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/09\/enhanced-car-t-cells-emerge-from-genetic-screening","title":{"rendered":"Enhanced CAR T cells emerge from genetic screening"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/enhanced-car-t-cells-emerge-from-genetic-screening2.jpg\"><\/a><\/p>\n<p>CAR T cells are patient-derived, genetically engineered immune cells. They are \u201cliving drugs\u201d and constitute a milestone in modern medicine. Equipping T cells, a key cell type of the immune system, with a \u201cchimeric antigen receptor\u201d (CAR) enables them to specifically recognize and attack cancer cells.<\/p>\n<p>CAR T cell therapy has demonstrated its potential by curing patients with otherwise untreatable blood cancers. But it still fails for most patients, often due to T cell intrinsic dysfunction. To address their current limitations and to make CAR T cells intrinsically stronger, scientists at the CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences and the Medical University of Vienna have developed a new method for systematic discovery of genetic boosters of CAR T cell function.<\/p>\n<p>The new study, <a href=\"https:\/\/www.nature.com\/articles\/s41586-025-09507-9\" target=\"_blank\">published<\/a> in <i><i>Nature<\/i>,<\/i> introduces CELLFIE, a CAR T cell engineering and high-content CRISPR screening platform, enabling researchers to systematically modify CAR T cells and evaluate their therapeutic potential.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>CAR T cells are patient-derived, genetically engineered immune cells. They are \u201cliving drugs\u201d and constitute a milestone in modern medicine. Equipping T cells, a key cell type of the immune system, with a \u201cchimeric antigen receptor\u201d (CAR) enables them to specifically recognize and attack cancer cells. CAR T cell therapy has demonstrated its potential by [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1902,11,412],"tags":[],"class_list":["post-222429","post","type-post","status-publish","format-standard","hentry","category-bioengineering","category-biotech-medical","category-genetics"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/222429","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=222429"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/222429\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=222429"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=222429"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=222429"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}