{"id":222331,"date":"2025-09-23T16:03:24","date_gmt":"2025-09-23T21:03:24","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/09\/how-a-key-enzyme-shapes-nucleus-formation-in-cell-division"},"modified":"2025-09-23T16:03:24","modified_gmt":"2025-09-23T21:03:24","slug":"how-a-key-enzyme-shapes-nucleus-formation-in-cell-division","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/09\/how-a-key-enzyme-shapes-nucleus-formation-in-cell-division","title":{"rendered":"How a key enzyme shapes nucleus formation in cell division"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/how-a-key-enzyme-shapes-nucleus-formation-in-cell-division.jpg\"><\/a><\/p>\n<p>Every time a eukaryotic cell divides, it faces a monumental challenge: It must carefully duplicate and divide its genetic material (chromosomes) equally, and then rebuild the nuclear envelope around the separated halves. If this process goes wrong, the resulting nuclei can be misshapen or disorganized\u2014features often seen in cancer and aging-related diseases.<\/p>\n<p>A new study from researchers at the Indian Institute of Science (IISc) and Universit\u00e9 Paris-Saclay reveals how a key enzyme called Aurora A helps cells pull off this feat. The findings are <a href=\"https:\/\/www.embopress.org\/doi\/full\/10.1038\/s44318-025-00564-4\" target=\"_blank\">published<\/a> in The EMBO Journal.<\/p>\n<p>In dividing cells, structures called spindle poles (or centrosomes) grow in size to generate the microtubule \u2018tracks\u2019 that pull chromosomes apart. Once this job is done, the spindle poles must shrink and disassemble so that the <a href=\"https:\/\/phys.org\/tags\/nuclear+envelope\/\" rel=\"tag\" class=\"\">nuclear envelope<\/a> can reform around the separated chromosomes.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Every time a eukaryotic cell divides, it faces a monumental challenge: It must carefully duplicate and divide its genetic material (chromosomes) equally, and then rebuild the nuclear envelope around the separated halves. If this process goes wrong, the resulting nuclei can be misshapen or disorganized\u2014features often seen in cancer and aging-related diseases. A new study [\u2026]<\/p>\n","protected":false},"author":732,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412,269],"tags":[],"class_list":["post-222331","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics","category-life-extension"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/222331","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/732"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=222331"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/222331\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=222331"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=222331"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=222331"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}