{"id":222250,"date":"2025-09-21T12:08:02","date_gmt":"2025-09-21T17:08:02","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/09\/gist-research-reveals-a-promising-new-target-to-thwart-alzheimers-decades-before-symptoms-start"},"modified":"2025-09-21T12:08:02","modified_gmt":"2025-09-21T17:08:02","slug":"gist-research-reveals-a-promising-new-target-to-thwart-alzheimers-decades-before-symptoms-start","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/09\/gist-research-reveals-a-promising-new-target-to-thwart-alzheimers-decades-before-symptoms-start","title":{"rendered":"GIST Research reveals a promising new target to thwart Alzheimer\u2019s decades before symptoms start"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/gist-research-reveals-a-promising-new-target-to-thwart-alzheimers-decades-before-symptoms-start2.jpg\"><\/a><\/p>\n<p>A person will have Alzheimer\u2019s years before ever knowing it. The disorienting erasure of memories, language, thoughts\u2014in essence, all that makes up one\u2019s unique sense of self\u2014is the final act of this enigmatic disease that spends decades disrupting vital processes and dismantling the brain\u2019s delicate structure.<\/p>\n<p>Once symptoms surface and doctors make a diagnosis, though, it can often be too late. Damage is widespread, impossible to reverse. No cure exists.<\/p>\n<p>Attempts to develop drugs that clear away toxic accumulations of amyloid-beta and tau proteins\u2014hallmarks of the disease that cause neurons to die\u2014have ended in hundreds of failed clinical trials. Today, some scientists are skeptical over whether removing amyloid plaques is even enough. Others have a hunch that the best line of attack won\u2019t target just one aspect of the disease, but many of them, all at once.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A person will have Alzheimer\u2019s years before ever knowing it. The disorienting erasure of memories, language, thoughts\u2014in essence, all that makes up one\u2019s unique sense of self\u2014is the final act of this enigmatic disease that spends decades disrupting vital processes and dismantling the brain\u2019s delicate structure. Once symptoms surface and doctors make a diagnosis, though, [\u2026]<\/p>\n","protected":false},"author":707,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,47],"tags":[],"class_list":["post-222250","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/222250","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/707"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=222250"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/222250\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=222250"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=222250"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=222250"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}