{"id":222005,"date":"2025-09-17T00:22:12","date_gmt":"2025-09-17T05:22:12","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/09\/new-study-sheds-light-on-how-exercise-helps-lose-weight"},"modified":"2025-09-17T00:22:12","modified_gmt":"2025-09-17T05:22:12","slug":"new-study-sheds-light-on-how-exercise-helps-lose-weight","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/09\/new-study-sheds-light-on-how-exercise-helps-lose-weight","title":{"rendered":"New study sheds light on how exercise helps lose weight"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/new-study-sheds-light-on-how-exercise-helps-lose-weight.jpg\"><\/a><\/p>\n<p>Researchers have provided new insights into how exercise helps lose weight. They discovered a mechanism by which the compound Lac-Phe, which is produced during exercise, reduces appetite in mice, leading to weight loss. The findings appeared in <a href=\"https:\/\/www.nature.com\/articles\/s42255-025-01377-9\" target=\"_blank\"><i>Nature Metabolism<\/i><\/a>.<\/p>\n<p>\u201cRegular exercise is considered a powerful way to lose weight and to protect from obesity-associated diseases, such as diabetes or heart conditions,\u201d said co-corresponding author Dr. Yang He, assistant professor of pediatrics\u2014neurology at Baylor and investigator at the Duncan NRI. \u201cExercise helps lose weight by increasing the amount of energy the body uses; however, it is likely that other mechanisms are also involved.\u201d<\/p>\n<p>The researchers previously discovered that Lac-Phe is the most increased metabolite\u2014a product of the body\u2019s metabolism\u2014in blood after intense exercise, not just in mice but also in humans and racehorses. The team\u2019s previous work showed that giving Lac-Phe to obese mice reduced how much they ate and helped them lose weight without <a href=\"https:\/\/medicalxpress.com\/tags\/negative+side+effects\/\" rel=\"tag\" class=\"\">negative side effects<\/a>. But until now, scientists didn\u2019t fully understand how Lac-Phe works to suppress <a href=\"https:\/\/medicalxpress.com\/tags\/appetite\/\" rel=\"tag\" class=\"\">appetite<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers have provided new insights into how exercise helps lose weight. They discovered a mechanism by which the compound Lac-Phe, which is produced during exercise, reduces appetite in mice, leading to weight loss. The findings appeared in Nature Metabolism. \u201cRegular exercise is considered a powerful way to lose weight and to protect from obesity-associated diseases, [\u2026]<\/p>\n","protected":false},"author":732,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,1495],"tags":[],"class_list":["post-222005","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-health"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/222005","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/732"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=222005"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/222005\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=222005"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=222005"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=222005"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}