{"id":221669,"date":"2025-09-10T15:02:49","date_gmt":"2025-09-10T20:02:49","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/09\/crisprs-efficiency-triples-with-dna-wrapped-nanoparticles"},"modified":"2025-09-10T15:02:49","modified_gmt":"2025-09-10T20:02:49","slug":"crisprs-efficiency-triples-with-dna-wrapped-nanoparticles","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/09\/crisprs-efficiency-triples-with-dna-wrapped-nanoparticles","title":{"rendered":"CRISPR\u2019s efficiency triples with DNA-wrapped nanoparticles"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/crisprs-efficiency-triples-with-dna-wrapped-nanoparticles.jpg\"><\/a><\/p>\n<p>EVANSTON, IL. \u2014 With the power to rewrite the genetic code underlying countless diseases, CRISPR holds immense promise to revolutionize medicine. But until scientists can deliver its gene-editing machinery safely and efficiently into relevant cells and tissues, that promise will remain out of reach.<\/p>\n<p>Now, Northwestern University chemists have unveiled a new type of nanostructure that dramatically improves CRISPR delivery and potentially extends its scope of utility.<\/p>\n<p>Called lipid nanoparticle spherical nucleic acids (LNP-SNAs), these tiny structures carry the full set of CRISPR editing tools \u2014 Cas9 enzymes, guide RNA and a DNA repair template \u2014 wrapped in a dense, protective shell of DNA. Not only does this DNA coating shield its cargo, but it also dictates which organs and tissues the LNP-SNAs travel to and makes it easier for them to enter cells.<\/p>\n<hr>\n<p>New system delivers CRISPR machinery more safely and effectively into cells.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>EVANSTON, IL. \u2014 With the power to rewrite the genetic code underlying countless diseases, CRISPR holds immense promise to revolutionize medicine. But until scientists can deliver its gene-editing machinery safely and efficiently into relevant cells and tissues, that promise will remain out of reach. Now, Northwestern University chemists have unveiled a new type of nanostructure [\u2026]<\/p>\n","protected":false},"author":534,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412,4],"tags":[],"class_list":["post-221669","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics","category-nanotechnology"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/221669","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/534"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=221669"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/221669\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=221669"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=221669"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=221669"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}