{"id":221665,"date":"2025-09-10T08:04:49","date_gmt":"2025-09-10T13:04:49","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/09\/how-capillary-constriction-triggers-metastasis"},"modified":"2025-09-10T08:04:49","modified_gmt":"2025-09-10T13:04:49","slug":"how-capillary-constriction-triggers-metastasis","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/09\/how-capillary-constriction-triggers-metastasis","title":{"rendered":"How capillary constriction triggers metastasis"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/how-capillary-constriction-triggers-metastasis2.jpg\"><\/a><\/p>\n<p>Nine of the 10 most common cancer deaths are caused by solid tumours, but in most cases it\u2019s the cancer\u2019s spread to other parts of the body \u2013 known as metastasis \u2013 that proves fatal.<\/p>\n<p>Now, researchers have uncovered a potential trigger for metastasis: the squeezing of cancer cells by the tiniest of veins that transforms them into a different type of cell now able to form new tumors.<\/p>\n<p>In a study published in <a href=\"https:\/\/www.nature.com\/articles\/s41467-025-63374-6\">Nature Communications<\/a>, the scientists described how they constructed a biomedical device that simulated blood flow through our narrowest blood veins. They showed that when human melanoma cancer cells are forced through channels narrower than 10 micrometres \u2013 about a fifth the width of a human hair \u2013 they begin to behave more like stem cells, gaining traits that could help them survive, spread, and form new tumors.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Nine of the 10 most common cancer deaths are caused by solid tumours, but in most cases it\u2019s the cancer\u2019s spread to other parts of the body \u2013 known as metastasis \u2013 that proves fatal. Now, researchers have uncovered a potential trigger for metastasis: the squeezing of cancer cells by the tiniest of veins that [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-221665","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/221665","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=221665"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/221665\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=221665"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=221665"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=221665"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}