{"id":221448,"date":"2025-09-05T03:27:34","date_gmt":"2025-09-05T08:27:34","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/09\/how-an-autism-linked-mutation-reduces-vasopressin-and-alters-social-behavior"},"modified":"2025-09-05T03:27:34","modified_gmt":"2025-09-05T08:27:34","slug":"how-an-autism-linked-mutation-reduces-vasopressin-and-alters-social-behavior","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/09\/how-an-autism-linked-mutation-reduces-vasopressin-and-alters-social-behavior","title":{"rendered":"How an autism-linked mutation reduces vasopressin and alters social behavior"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/how-an-autism-linked-mutation-reduces-vasopressin-and-alters-social-behavior.jpg\"><\/a><\/p>\n<p>A team of researchers has identified for the first time the mechanism linking a mutation in the Shank3 gene with alterations in social behavior. Using a mouse model carrying this autism-associated mutation, the study shows that vasopressin, a brain hormone essential for social relationships, is not properly released in the lateral septum.<\/p>\n<p>The team is from the Cognition and Social Interactions laboratory, led by F\u00e9lix Leroy at the Institute for Neurosciences, a joint center of the Spanish National Research Council (CSIC) and the Miguel Hern\u00e1ndez University (UMH) of Elche.<\/p>\n<p>The work, <a href=\"https:\/\/www.nature.com\/articles\/s41467-025-61994-6\" target=\"_blank\">published<\/a> in <i>Nature Communications<\/i>, demonstrates that the proper release of vasopressin in this region regulates social behaviors through two distinct receptor pathways: one controlling sociability and the other controlling social aggression, and that selective activation of these receptors can reverse deficits in social interaction without triggering unwanted aggressive responses.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A team of researchers has identified for the first time the mechanism linking a mutation in the Shank3 gene with alterations in social behavior. Using a mouse model carrying this autism-associated mutation, the study shows that vasopressin, a brain hormone essential for social relationships, is not properly released in the lateral septum. The team is [\u2026]<\/p>\n","protected":false},"author":427,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[412,47],"tags":[],"class_list":["post-221448","post","type-post","status-publish","format-standard","hentry","category-genetics","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/221448","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/427"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=221448"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/221448\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=221448"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=221448"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=221448"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}