{"id":221248,"date":"2025-08-31T15:14:30","date_gmt":"2025-08-31T20:14:30","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/08\/induced-somatic-mutation-accumulation-during-skeletal-muscle-regeneration-reduces-muscle-strength"},"modified":"2025-08-31T15:14:30","modified_gmt":"2025-08-31T20:14:30","slug":"induced-somatic-mutation-accumulation-during-skeletal-muscle-regeneration-reduces-muscle-strength","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/08\/induced-somatic-mutation-accumulation-during-skeletal-muscle-regeneration-reduces-muscle-strength","title":{"rendered":"Induced somatic mutation accumulation during skeletal muscle regeneration reduces muscle strength"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/induced-somatic-mutation-accumulation-during-skeletal-muscle-regeneration-reduces-muscle-strength.jpg\"><\/a><\/p>\n<p>With aging, somatic mutations accumulate in cellular DNA; however, whether they drive age-related functional decline is incompletely understood. Here the authors show that these mutations can weaken muscle repair and reduce strength after injury, suggesting they play a role in age-related physical decline in mouse muscle.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>With aging, somatic mutations accumulate in cellular DNA; however, whether they drive age-related functional decline is incompletely understood. Here the authors show that these mutations can weaken muscle repair and reduce strength after injury, suggesting they play a role in age-related physical decline in mouse muscle.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,269],"tags":[],"class_list":["post-221248","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-life-extension"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/221248","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=221248"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/221248\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=221248"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=221248"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=221248"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}