{"id":221050,"date":"2025-08-27T01:21:06","date_gmt":"2025-08-27T06:21:06","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/08\/distinct-prefrontal-pathways-shown-to-separate-reward-motivation-from-threat-reactivity"},"modified":"2025-08-27T01:21:06","modified_gmt":"2025-08-27T06:21:06","slug":"distinct-prefrontal-pathways-shown-to-separate-reward-motivation-from-threat-reactivity","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/08\/distinct-prefrontal-pathways-shown-to-separate-reward-motivation-from-threat-reactivity","title":{"rendered":"Distinct prefrontal pathways shown to separate reward motivation from threat reactivity"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/distinct-prefrontal-pathways-shown-to-separate-reward-motivation-from-threat-reactivity.jpg\"><\/a><\/p>\n<p>University of Cambridge researchers report that inactivating dorsolateral prefrontal cortex area 46 in marmosets blunts appetitive motivation and heightens threat reactivity, with effects mediated through asymmetric left-hemisphere pathways.<\/p>\n<p>The <a href=\"https:\/\/medicalxpress.com\/tags\/dorsolateral+prefrontal+cortex\/\" rel=\"tag\" class=\"\">dorsolateral prefrontal cortex<\/a> (dlPFC) is implicated in higher-order processes such as attention, abstract thought, working memory, and inhibitory control. It is also a target for noninvasive brain stimulation in <a href=\"https:\/\/medicalxpress.com\/tags\/treatment-resistant+depression\/\" rel=\"tag\" class=\"\">treatment-resistant depression<\/a>.<\/p>\n<p>Previous studies have shown that dlPFC transcranial magnetic stimulation improves depressive and comorbid anxiety symptoms and modulates activity in subcallosal cingulate cortex area 25, a region linked to therapeutic success.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>University of Cambridge researchers report that inactivating dorsolateral prefrontal cortex area 46 in marmosets blunts appetitive motivation and heightens threat reactivity, with effects mediated through asymmetric left-hemisphere pathways. The dorsolateral prefrontal cortex (dlPFC) is implicated in higher-order processes such as attention, abstract thought, working memory, and inhibitory control. It is also a target for noninvasive [\u2026]<\/p>\n","protected":false},"author":427,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[47],"tags":[],"class_list":["post-221050","post","type-post","status-publish","format-standard","hentry","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/221050","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/427"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=221050"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/221050\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=221050"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=221050"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=221050"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}