{"id":220288,"date":"2025-08-17T07:09:52","date_gmt":"2025-08-17T12:09:52","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/08\/brain-organoids-reveal-early-changes-in-familial-alzheimers"},"modified":"2025-08-17T07:09:52","modified_gmt":"2025-08-17T12:09:52","slug":"brain-organoids-reveal-early-changes-in-familial-alzheimers","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/08\/brain-organoids-reveal-early-changes-in-familial-alzheimers","title":{"rendered":"Brain Organoids Reveal Early Changes in Familial Alzheimer\u2019s"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/brain-organoids-reveal-early-changes-in-familial-alzheimers.jpg\"><\/a><\/p>\n<p>Researchers from ShanghaiTech University, including Zhen-Ge Luo, used brain organoids derived from individuals with fAD to examine disease-related changes that occur during early brain development. The organoids, which are lab-grown models of human brain tissue, displayed several features associated with AD: elevated amyloid protein accumulation, a reduction in mature neurons, increased cell death and gene expression differences relative to healthy controls.<\/p>\n<p><b>Role of thymosin \u03b24 in brain pathology<\/b><\/p>\n<p>Among the differentially expressed genes, the researchers identified TMSB4X, which encodes thymosin \u03b24 (T\u03b24), a protein with anti-inflammatory properties. TMSB4X expression was reduced in both the fAD organoids and in neurons from post-mortem samples of individuals with AD, suggesting a possible link between lower T\u03b24 levels and disease pathology.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers from ShanghaiTech University, including Zhen-Ge Luo, used brain organoids derived from individuals with fAD to examine disease-related changes that occur during early brain development. The organoids, which are lab-grown models of human brain tissue, displayed several features associated with AD: elevated amyloid protein accumulation, a reduction in mature neurons, increased cell death and gene [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,47],"tags":[],"class_list":["post-220288","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/220288","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=220288"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/220288\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=220288"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=220288"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=220288"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}