{"id":220027,"date":"2025-08-13T12:10:45","date_gmt":"2025-08-13T17:10:45","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/08\/releasing-a-molecular-brake-on-t-cells-could-supercharge-cancer-immunotherapy"},"modified":"2025-08-13T12:10:45","modified_gmt":"2025-08-13T17:10:45","slug":"releasing-a-molecular-brake-on-t-cells-could-supercharge-cancer-immunotherapy","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/08\/releasing-a-molecular-brake-on-t-cells-could-supercharge-cancer-immunotherapy","title":{"rendered":"Releasing a molecular brake on T cells could supercharge cancer immunotherapy"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/releasing-a-molecular-brake-on-t-cells-could-supercharge-cancer-immunotherapy2.jpg\"><\/a><\/p>\n<p>In a discovery that could expand the array of current cancer immunotherapy treatments, scientists at Harvard Medical School have identified a new molecular brake that hinders the ability of T cells to attack tumors.<\/p>\n<p>The research, published in <a href=\"https:\/\/www.nature.com\/articles\/s41590-025-02231-6\" target=\"_blank\"><i>Nature Immunology<\/i><\/a>, offers a new pathway to design treatments that help more patients\u2014a welcome development given that current <a href=\"https:\/\/medicalxpress.com\/tags\/cancer\/\" rel=\"tag\" class=\"\">cancer<\/a> immunotherapies work in <a href=\"https:\/\/www.mdpi.com\/2039-7283\/13\/1\/3\" target=\"_blank\">less than half of those<\/a> who receive them.<\/p>\n<p>The research, done in mice and in <a href=\"https:\/\/medicalxpress.com\/tags\/human+cells\/\" rel=\"tag\" class=\"\">human cells<\/a>, shows that a protein called STUB1 restrains the immune system\u2019s elite cancer-fighting CD8<sup>+<\/sup> T cells. It does so by interfering with immune-signaling receptors\u2014particularly one for the molecule IL-27\u2014that are crucial for T cells\u2019 ability to mount a vigorous anti-tumor response.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>In a discovery that could expand the array of current cancer immunotherapy treatments, scientists at Harvard Medical School have identified a new molecular brake that hinders the ability of T cells to attack tumors. The research, published in Nature Immunology, offers a new pathway to design treatments that help more patients\u2014a welcome development given that [\u2026]<\/p>\n","protected":false},"author":396,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-220027","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/220027","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/396"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=220027"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/220027\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=220027"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=220027"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=220027"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}