{"id":219606,"date":"2025-08-07T16:11:24","date_gmt":"2025-08-07T21:11:24","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/08\/first-gene-edited-islet-transplant-in-a-human-passes-functional-trial"},"modified":"2025-08-07T16:11:24","modified_gmt":"2025-08-07T21:11:24","slug":"first-gene-edited-islet-transplant-in-a-human-passes-functional-trial","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/08\/first-gene-edited-islet-transplant-in-a-human-passes-functional-trial","title":{"rendered":"First gene-edited islet transplant in a human passes functional trial"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/first-gene-edited-islet-transplant-in-a-human-passes-functional-trial2.jpg\"><\/a><\/p>\n<p>Uppsala University Hospital-led investigators report that gene-edited donor islet cells survived 12 weeks inside a man with long-standing type 1 diabetes without any immunosuppressive medication.<\/p>\n<p>Intensive insulin therapy can delay complications and improve life expectancy. Early-onset type 1 diabetes remains linked to reduced quality of life, serious cardiovascular risk, and shortened lifespan. Toxicity from lifelong immune suppression also drives morbidity and mortality in organ recipients.<\/p>\n<p>In the study, \u201cSurvival of Transplanted Allogeneic Beta Cells with No Immunosuppression,\u201d <a href=\"http:\/\/www.nejm.org\/doi\/10.1056\/NEJMoa2503822\" target=\"_blank\">published<\/a> in the <i>New England Journal of Medicine<\/i>, researchers conducted a first-in-human open-label trial to test whether hypoimmune-engineered islet cells could evade rejection.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Uppsala University Hospital-led investigators report that gene-edited donor islet cells survived 12 weeks inside a man with long-standing type 1 diabetes without any immunosuppressive medication. Intensive insulin therapy can delay complications and improve life expectancy. Early-onset type 1 diabetes remains linked to reduced quality of life, serious cardiovascular risk, and shortened lifespan. Toxicity from lifelong [\u2026]<\/p>\n","protected":false},"author":396,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1902,11,412],"tags":[],"class_list":["post-219606","post","type-post","status-publish","format-standard","hentry","category-bioengineering","category-biotech-medical","category-genetics"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/219606","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/396"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=219606"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/219606\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=219606"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=219606"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=219606"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}