{"id":219538,"date":"2025-08-06T20:05:09","date_gmt":"2025-08-07T01:05:09","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/08\/scientists-develop-method-to-optimize-delivery-of-mrna-to-cells"},"modified":"2025-08-06T20:05:09","modified_gmt":"2025-08-07T01:05:09","slug":"scientists-develop-method-to-optimize-delivery-of-mrna-to-cells","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/08\/scientists-develop-method-to-optimize-delivery-of-mrna-to-cells","title":{"rendered":"Scientists develop method to optimize delivery of mRNA to cells"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/scientists-develop-method-to-optimize-delivery-of-mrna-to-cells2.jpg\"><\/a><\/p>\n<p>Researchers have developed a simple yet highly effective method for delivering mRNA to target cells, opening up new possibilities for future non-vaccine mRNA medicines for a broad range of diseases.<\/p>\n<p>The Monash University study, <a href=\"https:\/\/www.nature.com\/articles\/s41565-025-01954-9\" target=\"_blank\">published<\/a> in <i>Nature Nanotechnology<\/i>, is a significant development in how mRNA is precisely delivered to cells to maximize efficacy and minimize off-target effects\u2014vital components for future mRNA medicines as they continue to evolve.<\/p>\n<p>Led by the Monash Institute of Pharmaceutical Scientists (MIPS), the interdisciplinary team of researchers used advanced technologies coupled with preclinical studies to produce a highly versatile method that captures and attaches antibodies to the surface of mRNA-loaded <a href=\"https:\/\/phys.org\/tags\/lipid+nanoparticles\/\" rel=\"tag\" class=\"\">lipid nanoparticles<\/a> while the antibodies are in their optimal orientation, thus enhancing the mRNA\u2019s effectiveness and reducing side effects by making sure it only reaches its target destination.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers have developed a simple yet highly effective method for delivering mRNA to target cells, opening up new possibilities for future non-vaccine mRNA medicines for a broad range of diseases. The Monash University study, published in Nature Nanotechnology, is a significant development in how mRNA is precisely delivered to cells to maximize efficacy and minimize [\u2026]<\/p>\n","protected":false},"author":396,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,4],"tags":[],"class_list":["post-219538","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-nanotechnology"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/219538","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/396"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=219538"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/219538\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=219538"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=219538"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=219538"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}