{"id":219436,"date":"2025-08-05T08:03:12","date_gmt":"2025-08-05T13:03:12","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/08\/stem-cells-created-from-als-patients-point-to-potential-new-target-for-treatment"},"modified":"2025-08-05T08:03:12","modified_gmt":"2025-08-05T13:03:12","slug":"stem-cells-created-from-als-patients-point-to-potential-new-target-for-treatment","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/08\/stem-cells-created-from-als-patients-point-to-potential-new-target-for-treatment","title":{"rendered":"Stem cells created from ALS patients point to potential new target for treatment"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/stem-cells-created-from-als-patients-point-to-potential-new-target-for-treatment.jpg\"><\/a><\/p>\n<p>Amyotrophic lateral sclerosis (ALS), known as Lou Gehrig\u2019s disease, is an incurable neurological disorder affecting motor neurons\u2014nerve cells in the brain and spinal cord that control voluntary muscle movement and breathing.<\/p>\n<p>Many ALS <a href=\"https:\/\/medicalxpress.com\/tags\/clinical+trials\/\" rel=\"tag\" class=\"\">clinical trials<\/a>, including those testing promising drugs, have fallen short of expectations\u2014often because the extent of the disease can vary, and patients don\u2019t respond the same way to medications.<\/p>\n<p>But a new study led by scientists at Case Western Reserve University used <a href=\"https:\/\/medicalxpress.com\/tags\/stem+cells\/\" rel=\"tag\" class=\"\">stem cells<\/a> created from ALS patients to target a specific gene as a kind of shut-off valve for what stresses <a href=\"https:\/\/medicalxpress.com\/tags\/nerve+cells\/\" rel=\"tag\" class=\"\">nerve cells <\/a>\u2014and it worked.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Amyotrophic lateral sclerosis (ALS), known as Lou Gehrig\u2019s disease, is an incurable neurological disorder affecting motor neurons\u2014nerve cells in the brain and spinal cord that control voluntary muscle movement and breathing. Many ALS clinical trials, including those testing promising drugs, have fallen short of expectations\u2014often because the extent of the disease can vary, and patients [\u2026]<\/p>\n","protected":false},"author":732,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,47],"tags":[],"class_list":["post-219436","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/219436","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/732"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=219436"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/219436\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=219436"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=219436"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=219436"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}