{"id":219392,"date":"2025-08-04T16:09:46","date_gmt":"2025-08-04T21:09:46","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/08\/the-predictive-value-of-endocan-as-a-novel-biomarker-an-umbrella-study-on-meta-analyses"},"modified":"2025-08-04T16:09:46","modified_gmt":"2025-08-04T21:09:46","slug":"the-predictive-value-of-endocan-as-a-novel-biomarker-an-umbrella-study-on-meta-analyses","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/08\/the-predictive-value-of-endocan-as-a-novel-biomarker-an-umbrella-study-on-meta-analyses","title":{"rendered":"The predictive value of endocan as a novel biomarker: an umbrella study on meta-analyses"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/the-predictive-value-of-endocan-as-a-novel-biomarker-an-umbrella-study-on-meta-analyses2.jpg\"><\/a><\/p>\n<p>In recent years, endocan has emerged as a potential biomarker in various medical conditions. This multifaceted molecule, involved in key processes such as inflammation and endothelial dysfunction, has shown promise in predicting disease progression and therapeutic response across a spectrum of pathologies. However, the heterogeneity of studies and the complexity of endocan\u2019s role in different diseases necessitate a comprehensive review. This umbrella review aimed to systematically synthesize and evaluate the evidence from multiple meta-analyses, offering a view of endocan\u2019s effectiveness as a predictive biomarker in medical diseases.<\/p>\n<p>An extensive search was carried out on March 12, 2024, using the following four databases: PubMed, Scopus, Web of Science, and Cochrane Library. The goal was to identify meta-analyses that assess endocan\u2019s predictive efficacy. The pooled effect size and its 95% confidence interval were taken out of each discovered meta-analysis. Furthermore, power analyses were performed to assess the robustness and dependability of the results. An additional GRADE assessment was carried out to gauge the epidemiological reliability of the findings.<\/p>\n<p>In the final analysis, 12 meta-analyses were included in the current umbrella review. The results showed that there is a significant correlation between a higher endocan level and COVID-19 (SMD: 1.40, 95% CI 0.21\u20132.58, P = 0.02), followed by chronic kidney disease (SMD: 1.34, 95% CI 0.20 to 2.48, P 0.01), obstructive sleep apnea (SMD: 1.30, 95% CI 1.06\u20131.54, P 0.01), diabetes mellitus (SMD: 1.00, 95% CI 0.81 to 1.19, P 0.01), coronary artery disease (SMD: 0.99, 95% CI 0.58\u20131.39, P 0.01), hypertension (SMD: 0.91, 95% CI 0.44\u20131.38, P 0.01), and preeclampsia (SMD: 0.37, 95% CI 0.13\u20130.62, P 0.01).<\/p>\n","protected":false},"excerpt":{"rendered":"<p>In recent years, endocan has emerged as a potential biomarker in various medical conditions. This multifaceted molecule, involved in key processes such as inflammation and endothelial dysfunction, has shown promise in predicting disease progression and therapeutic response across a spectrum of pathologies. However, the heterogeneity of studies and the complexity of endocan\u2019s role in different [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-219392","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/219392","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=219392"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/219392\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=219392"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=219392"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=219392"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}