{"id":219317,"date":"2025-08-03T00:08:14","date_gmt":"2025-08-03T05:08:14","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/08\/terminal-renal-failure-as-a-contributor-to-high-sensitivity-cardiac-troponin-t-elevations-insights-from-patients-undergoing-renal-transplantation"},"modified":"2025-08-03T00:08:14","modified_gmt":"2025-08-03T05:08:14","slug":"terminal-renal-failure-as-a-contributor-to-high-sensitivity-cardiac-troponin-t-elevations-insights-from-patients-undergoing-renal-transplantation","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/08\/terminal-renal-failure-as-a-contributor-to-high-sensitivity-cardiac-troponin-t-elevations-insights-from-patients-undergoing-renal-transplantation","title":{"rendered":"Terminal renal failure as a contributor to high-sensitivity cardiac troponin T elevations: insights from patients undergoing renal transplantation"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/terminal-renal-failure-as-a-contributor-to-high-sensitivity-cardiac-troponin-t-elevations-insights-from-patients-undergoing-renal-transplantation2.jpg\"><\/a><\/p>\n<p><strong>Background<\/strong> False cardiac troponin (cTn) elevations from non-cardiac causes are a major concern. We aimed to assess terminal renal failure as a possible non-cardiac cause of elevated high-sensitivity cTnT (hs-cTnT) concentrations using renal transplantation as an in vivo model of rapid restoration of renal function.<\/p>\n<p><strong>Methods<\/strong> We analysed consecutive patients with end-stage renal disease (ESRD) undergoing renal transplantation at a single centre. Patients with perioperative myocardial infarction or injury were excluded. Changes in hs-cTnT and creatinine were measured pretransplant and at four post-transplant intervals (day 1, days 2\u20135 and days 14\u2013180). A decrease of \u226525% in hs-cTnT within 24 hours post-transplant was deemed evidence of renal clearance recovery.<\/p>\n<p>Results Among 45 patients (median age 67 years, 31% women), the median pretransplant plasma creatinine concentration was 608 \u03bcmol\/L (IQR 482\u2013830), and fell to 425 \u03bcmol\/L (IQR 337\u2013619) on day 1289 \u03bcmol\/L (IQR 201\u2013492) on days 2\u20135 and 126 \u03bcmol\/L (IQR 103\u2013191) on days 14\u2013180 (p0.001, p0.001 and p=0.003, respectively). The median pretransplant hs-cTnT concentration was 48 ng\/L (IQR 34\u201370). It fell to 26 ng\/L (IQR 15\u201338; geometric mean of relative change 36%) on day 1 (p0.001) and then remained constant on days 2\u20135 (26 ng\/L (IQR 18\u201335)) and days 14\u2013180 (25 ng\/L (IQR 20\u201330), p=ns).<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Background False cardiac troponin (cTn) elevations from non-cardiac causes are a major concern. We aimed to assess terminal renal failure as a possible non-cardiac cause of elevated high-sensitivity cTnT (hs-cTnT) concentrations using renal transplantation as an in vivo model of rapid restoration of renal function. Methods We analysed consecutive patients with end-stage renal disease (ESRD) [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-219317","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/219317","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=219317"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/219317\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=219317"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=219317"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=219317"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}