{"id":219294,"date":"2025-08-02T12:07:54","date_gmt":"2025-08-02T17:07:54","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/08\/researchers-harness-ai-powered-protein-design-to-enhance-t-cell-based-immunotherapies"},"modified":"2025-08-02T12:07:54","modified_gmt":"2025-08-02T17:07:54","slug":"researchers-harness-ai-powered-protein-design-to-enhance-t-cell-based-immunotherapies","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/08\/researchers-harness-ai-powered-protein-design-to-enhance-t-cell-based-immunotherapies","title":{"rendered":"Researchers harness AI-powered protein design to enhance T-cell based immunotherapies"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/researchers-harness-ai-powered-protein-design-to-enhance-t-cell-based-immunotherapies.jpg\"><\/a><\/p>\n<p>A paper <a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(25)00798-6\" target=\"_blank\">published<\/a> in <i>Cell<\/i> highlights how researchers have leveraged AI-based computational protein design to create a novel synthetic ligand that activates the Notch signaling pathway, a key driver in T-cell development and function.<\/p>\n<p>These so-called soluble Notch agonists can be broadly applied to optimize clinical T-cell production and advance immunotherapy development.<\/p>\n<p>Notch signaling is central to many cellular differentiation processes and is essential in transforming human immune cells into T-cells that target viruses and tumors. But activating Notch signaling in the laboratory has posed a challenge.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A paper published in Cell highlights how researchers have leveraged AI-based computational protein design to create a novel synthetic ligand that activates the Notch signaling pathway, a key driver in T-cell development and function. These so-called soluble Notch agonists can be broadly applied to optimize clinical T-cell production and advance immunotherapy development. Notch signaling is [\u2026]<\/p>\n","protected":false},"author":396,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,6],"tags":[],"class_list":["post-219294","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-robotics-ai"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/219294","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/396"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=219294"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/219294\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=219294"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=219294"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=219294"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}