{"id":219286,"date":"2025-08-02T08:13:53","date_gmt":"2025-08-02T13:13:53","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/08\/melanoma-cellular-compass-discovery-could-help-curb-metastasis"},"modified":"2025-08-02T08:13:53","modified_gmt":"2025-08-02T13:13:53","slug":"melanoma-cellular-compass-discovery-could-help-curb-metastasis","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/08\/melanoma-cellular-compass-discovery-could-help-curb-metastasis","title":{"rendered":"Melanoma \u2018cellular compass\u2019 discovery could help curb metastasis"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/melanoma-cellular-compass-discovery-could-help-curb-metastasis.jpg\"><\/a><\/p>\n<p>Researchers have discovered a protein which is critical for steering melanoma cancer cells as they spread throughout the body. The malignant cells become dependent on this protein to migrate, pointing to new strategies for impeding metastasis.<\/p>\n<p>The protein eIF2A is generally thought to spring into action when a cell is under stress, helping ribosomes launch protein synthesis. But according to a study <a href=\"https:\/\/www.science.org\/doi\/10.1126\/sciadv.adu5668\" target=\"_blank\">published<\/a> in the journal <i>Science Advances<\/i>, eIF2A has a completely different role in melanoma, helping <a href=\"https:\/\/medicalxpress.com\/tags\/cancerous+cells\/\" rel=\"tag\" class=\"\">cancerous cells<\/a> control movement.<\/p>\n<p>\u201cMalignant cells that metastasize need to make their way through tissues in order to invade proximal or distant organs. Targeting eIF2A could be a new strategy to impede melanoma breaking free and seeding tumors elsewhere,\u201d says Dr. F\u00e1tima Gebauer, corresponding author of the study and researcher at the Center for Genomic Regulation (CRG) in Barcelona.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers have discovered a protein which is critical for steering melanoma cancer cells as they spread throughout the body. The malignant cells become dependent on this protein to migrate, pointing to new strategies for impeding metastasis. The protein eIF2A is generally thought to spring into action when a cell is under stress, helping ribosomes launch [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-219286","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/219286","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=219286"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/219286\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=219286"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=219286"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=219286"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}