{"id":219272,"date":"2025-08-02T04:14:08","date_gmt":"2025-08-02T09:14:08","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/08\/serotonin-receptor-signaling-insights-may-pave-way-for-next-gen-mental-health-drugs"},"modified":"2025-08-02T04:14:08","modified_gmt":"2025-08-02T09:14:08","slug":"serotonin-receptor-signaling-insights-may-pave-way-for-next-gen-mental-health-drugs","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/08\/serotonin-receptor-signaling-insights-may-pave-way-for-next-gen-mental-health-drugs","title":{"rendered":"Serotonin receptor signaling insights may pave way for next-gen mental health drugs"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/serotonin-receptor-signaling-insights-may-pave-way-for-next-gen-mental-health-drugs2.jpg\"><\/a><\/p>\n<p>In a discovery that could guide the development of next-generation antidepressants and antipsychotic medications, researchers at the Icahn School of Medicine at Mount Sinai have developed new insights into how a critical brain receptor works at the molecular level and why that matters for mental health treatments.<\/p>\n<p>The study, <a href=\"https:\/\/www.science.org\/doi\/10.1126\/sciadv.adu9851\" target=\"_blank\">published<\/a> in the online issue of <i>Science Advances<\/i>, focuses on the 5-HT1A <a href=\"https:\/\/medicalxpress.com\/tags\/serotonin+receptor\/\" rel=\"tag\" class=\"\">serotonin receptor<\/a>, a major player in regulating mood and a common target of both traditional antidepressants and newer therapies such as psychedelics. The paper is titled \u201cStructural determinants of G protein subtype selectivity at the serotonin receptor 5-HT1A.\u201d<\/p>\n<p>Despite its clinical importance, this receptor has remained poorly understood, with many of its molecular and pharmacological properties largely understudied\u2014until now.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>In a discovery that could guide the development of next-generation antidepressants and antipsychotic medications, researchers at the Icahn School of Medicine at Mount Sinai have developed new insights into how a critical brain receptor works at the molecular level and why that matters for mental health treatments. The study, published in the online issue of [\u2026]<\/p>\n","protected":false},"author":427,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,47],"tags":[],"class_list":["post-219272","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/219272","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/427"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=219272"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/219272\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=219272"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=219272"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=219272"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}