{"id":219245,"date":"2025-08-01T16:10:42","date_gmt":"2025-08-01T21:10:42","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/08\/lipid-nanoparticle-stereochemistry-shapes-mrna-delivery-safety-and-efficacy-study-reveals"},"modified":"2025-08-01T16:10:42","modified_gmt":"2025-08-01T21:10:42","slug":"lipid-nanoparticle-stereochemistry-shapes-mrna-delivery-safety-and-efficacy-study-reveals","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/08\/lipid-nanoparticle-stereochemistry-shapes-mrna-delivery-safety-and-efficacy-study-reveals","title":{"rendered":"Lipid nanoparticle stereochemistry shapes mRNA delivery safety and efficacy, study reveals"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/lipid-nanoparticle-stereochemistry-shapes-mrna-delivery-safety-and-efficacy-study-reveals2.jpg\"><\/a><\/p>\n<p>A team from the Max-Planck-Institut f\u00fcr Kohlenforschung, Hokkaido University, and Osaka University has discovered that subtle differences in molecular structure can have a major impact on the performance of mRNA-based drugs. Their findings, <a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/jacs.5c08345\" target=\"_blank\">published<\/a> in the <i>Journal of the American Chemical Society<\/i>, open the door to the development of safer and more effective vaccines and therapies.<\/p>\n<p>To deliver therapeutic nucleic acids like mRNA into cells, scientists rely on <a href=\"https:\/\/phys.org\/tags\/lipid+nanoparticles\/\" rel=\"tag\" class=\"\">lipid nanoparticles<\/a> (LNPs)\u2014tiny, fat-based carriers that protect fragile genetic material, enabling it to survive in the body and reach target cells. A key component of these LNPs are ionizable lipids, which help mRNA enter cells and then release it effectively. One such lipid, ALC-315, was notably used in the Pfizer\/BioNTech COVID-19 vaccine, a medical breakthrough that played a critical role in controlling the global pandemic.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A team from the Max-Planck-Institut f\u00fcr Kohlenforschung, Hokkaido University, and Osaka University has discovered that subtle differences in molecular structure can have a major impact on the performance of mRNA-based drugs. Their findings, published in the Journal of the American Chemical Society, open the door to the development of safer and more effective vaccines and [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,19,412,4],"tags":[],"class_list":["post-219245","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-chemistry","category-genetics","category-nanotechnology"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/219245","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=219245"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/219245\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=219245"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=219245"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=219245"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}