{"id":219040,"date":"2025-07-30T04:18:54","date_gmt":"2025-07-30T09:18:54","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/07\/human-proteome-study-maps-aging-signatures-across-13-organs"},"modified":"2025-07-30T04:18:54","modified_gmt":"2025-07-30T09:18:54","slug":"human-proteome-study-maps-aging-signatures-across-13-organs","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/07\/human-proteome-study-maps-aging-signatures-across-13-organs","title":{"rendered":"Human proteome study maps aging signatures across 13 organs"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/human-proteome-study-maps-aging-signatures-across-13-organs2.jpg\"><\/a><\/p>\n<p>A multi-institutional team led by the Chinese Academy of Sciences has constructed a proteomic atlas of human aging across 13 organs, revealing tissue-specific aging clocks, transcriptome-proteome decoupling, and secreted proteins that may accelerate systemic decline.<\/p>\n<p>Organ-specific aging and deterioration drive vulnerability to chronic diseases. Previous studies focused primarily on plasma proteins or DNA methylation profiles. No investigation has systematically mapped how protein quality control deteriorates differently across tissues identified organ\u2011specific biological age biomarkers.<\/p>\n<p>In the study, \u201cComprehensive human proteome profiles across a 50-year lifespan reveal aging trajectories and signatures,\u201d <a href=\"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0092867425007494\" target=\"_blank\">published<\/a> in <i>Cell<\/i>, researchers designed a multi-tissue <a href=\"https:\/\/medicalxpress.com\/tags\/proteomic+analysis\/\" rel=\"tag\" class=\"\">proteomic analysis<\/a>, charting organ-level protein dynamics and aging-related biomarkers across five decades of adult life to construct a longitudinal proteomic atlas of human aging.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A multi-institutional team led by the Chinese Academy of Sciences has constructed a proteomic atlas of human aging across 13 organs, revealing tissue-specific aging clocks, transcriptome-proteome decoupling, and secreted proteins that may accelerate systemic decline. Organ-specific aging and deterioration drive vulnerability to chronic diseases. Previous studies focused primarily on plasma proteins or DNA methylation profiles. [\u2026]<\/p>\n","protected":false},"author":427,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,269],"tags":[],"class_list":["post-219040","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-life-extension"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/219040","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/427"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=219040"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/219040\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=219040"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=219040"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=219040"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}