{"id":219018,"date":"2025-07-30T00:03:01","date_gmt":"2025-07-30T05:03:01","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/07\/new-findings-reveal-how-%ce%b2-cell-subtypes-influence-type-2-diabetes-development"},"modified":"2025-07-30T00:03:01","modified_gmt":"2025-07-30T05:03:01","slug":"new-findings-reveal-how-%ce%b2-cell-subtypes-influence-type-2-diabetes-development","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/07\/new-findings-reveal-how-%ce%b2-cell-subtypes-influence-type-2-diabetes-development","title":{"rendered":"New findings reveal how \u03b2-cell subtypes influence type 2 diabetes development"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/new-findings-reveal-how-ceb2-cell-subtypes-influence-type-2-diabetes-development2.jpg\"><\/a><\/p>\n<p>If it has seemed like more people you know are developing diabetes, you are right. The diabetes epidemic is not called an epidemic for nothing: According to the American Diabetes Association, over 10% of the U.S. population\u2014approximately 38.4 million people\u2014had diabetes in 2021, and 1.2 million more people get diagnosed each year.<\/p>\n<p>Type 2 diabetes occurs when your body develops a resistance to insulin, the hormone that helps regulate glucose levels in your blood. Insulin is secreted by <a href=\"https:\/\/medicalxpress.com\/tags\/pancreatic+cells\/\" rel=\"tag\" class=\"\">pancreatic cells<\/a> called \u03b2-cells, and in T2D, they ramp up insulin production to try to regulate blood glucose levels, but even that is insufficient and the \u03b2-cells eventually become exhausted over time. Thanks to their importance, the functional \u03b2-cell mass, or the total number of \u03b2-cells and their function, determines a person\u2019s risk of diabetes.<\/p>\n<p>\u0392-cells are not homogeneous, even within a single individual, and consist of different \u201csubtypes,\u201d each with their own secretory function, viability, and ability to divide. In other words, each \u03b2-cell subtype has a different level of fitness, and the higher, the better. When diabetes develops, the proportions of some \u03b2-cell subtypes are changed. But a key question remains: Are the proportion and fitness of different \u03b2-cell subtypes altered by diabetes or are the changes responsible for the disease?<\/p>\n","protected":false},"excerpt":{"rendered":"<p>If it has seemed like more people you know are developing diabetes, you are right. The diabetes epidemic is not called an epidemic for nothing: According to the American Diabetes Association, over 10% of the U.S. population\u2014approximately 38.4 million people\u2014had diabetes in 2021, and 1.2 million more people get diagnosed each year. Type 2 diabetes [\u2026]<\/p>\n","protected":false},"author":732,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-219018","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/219018","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/732"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=219018"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/219018\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=219018"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=219018"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=219018"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}