{"id":218901,"date":"2025-07-28T12:04:35","date_gmt":"2025-07-28T17:04:35","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/07\/researchers-discover-how-microglia-engulf-and-break-down-amyloid-beta-a-protein-that-builds-up-in-alzheimers"},"modified":"2025-07-28T12:04:35","modified_gmt":"2025-07-28T17:04:35","slug":"researchers-discover-how-microglia-engulf-and-break-down-amyloid-beta-a-protein-that-builds-up-in-alzheimers","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/07\/researchers-discover-how-microglia-engulf-and-break-down-amyloid-beta-a-protein-that-builds-up-in-alzheimers","title":{"rendered":"Researchers discover how microglia engulf and break down amyloid beta, a protein that builds up in Alzheimer\u2019s"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/researchers-discover-how-microglia-engulf-and-break-down-amyloid-beta-a-protein-that-builds-up-in-alzheimers.jpg\"><\/a><\/p>\n<p>In Alzheimer\u2019s disease, proteins like amyloid beta form clumps, known as plaques, that damage the brain.<\/p>\n<p>But in some people, <a href=\"https:\/\/medicalxpress.com\/tags\/immune+cells\/\" rel=\"tag\" class=\"\">immune cells<\/a> called microglia break down these proteins before they can cause harm. This leads to fewer and smaller clumps\u2014and much milder symptoms.<\/p>\n<p>Researchers at UC San Francisco identified a molecular receptor that enables microglia to gobble up and digest amyloid beta plaques. The findings are <a href=\"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0896627325004787\" target=\"_blank\">published<\/a> in the journal Neuron.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>In Alzheimer\u2019s disease, proteins like amyloid beta form clumps, known as plaques, that damage the brain. But in some people, immune cells called microglia break down these proteins before they can cause harm. This leads to fewer and smaller clumps\u2014and much milder symptoms. Researchers at UC San Francisco identified a molecular receptor that enables microglia [\u2026]<\/p>\n","protected":false},"author":732,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,47],"tags":[],"class_list":["post-218901","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/218901","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/732"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=218901"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/218901\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=218901"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=218901"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=218901"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}