{"id":218799,"date":"2025-07-26T20:03:03","date_gmt":"2025-07-27T01:03:03","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/07\/hormone-found-to-suppress-immune-cells-allowing-cancer-to-evade-detection"},"modified":"2025-07-26T20:03:03","modified_gmt":"2025-07-27T01:03:03","slug":"hormone-found-to-suppress-immune-cells-allowing-cancer-to-evade-detection","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/07\/hormone-found-to-suppress-immune-cells-allowing-cancer-to-evade-detection","title":{"rendered":"Hormone found to suppress immune cells, allowing cancer to evade detection"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/hormone-found-to-suppress-immune-cells-allowing-cancer-to-evade-detection.jpg\"><\/a><\/p>\n<p>Researchers at UT Southwestern Medical Center have discovered how a hormone interacts with a receptor on the surface of immune cells to shield cancer cells from the body\u2019s natural defenses.<\/p>\n<p>The findings, published in <a href=\"https:\/\/www.nature.com\/articles\/s41590-025-02233-4\" target=\"_blank\"><i>Nature Immunology<\/i><\/a>, could lead to new immunotherapy approaches for treating cancer as well as potential treatments for inflammatory disorders and neurologic diseases.<\/p>\n<p>\u201cMyeloid cells are among the first group of <a href=\"https:\/\/medicalxpress.com\/tags\/immune+cells\/\" rel=\"tag\" class=\"\">immune cells<\/a> recruited to tumors, but very quickly these tumor-fighting cells turn into tumor-supporting cells. Our study suggests that receptors on these <a href=\"https:\/\/medicalxpress.com\/tags\/myeloid+cells\/\" rel=\"tag\" class=\"\">myeloid cells<\/a> get stimulated by this hormone and end up suppressing the immune system,\u201d said Cheng Cheng \u201cAlec\u201d Zhang, Ph.D., Professor of Physiology and a member of the Harold C. Simmons Comprehensive Cancer Center at UT Southwestern. Dr. Zhang co-led the study with first author Xing Yang, Ph.D., a postdoctoral researcher in the Zhang Lab.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers at UT Southwestern Medical Center have discovered how a hormone interacts with a receptor on the surface of immune cells to shield cancer cells from the body\u2019s natural defenses. The findings, published in Nature Immunology, could lead to new immunotherapy approaches for treating cancer as well as potential treatments for inflammatory disorders and neurologic [\u2026]<\/p>\n","protected":false},"author":511,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-218799","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/218799","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/511"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=218799"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/218799\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=218799"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=218799"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=218799"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}