{"id":218790,"date":"2025-07-26T12:10:22","date_gmt":"2025-07-26T17:10:22","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/07\/scientists-find-2-existing-drugs-can-reverse-alzheimers-brain-damage-in-mice"},"modified":"2025-07-26T12:10:22","modified_gmt":"2025-07-26T17:10:22","slug":"scientists-find-2-existing-drugs-can-reverse-alzheimers-brain-damage-in-mice","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/07\/scientists-find-2-existing-drugs-can-reverse-alzheimers-brain-damage-in-mice","title":{"rendered":"Scientists Find 2 Existing Drugs Can Reverse Alzheimer\u2019s Brain Damage in Mice"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/scientists-find-2-existing-drugs-can-reverse-alzheimers-brain-damage-in-mice.jpg\"><\/a><\/p>\n<p>In efforts to beat <a href=\"https:\/\/www.sciencealert.com\/go\/IaO\" rel=\"nofollow\" target=\"_self\">Alzheimer\u2019s<\/a> disease, researchers are looking at existing drugs that could tackle the condition, and a new study identifies two promising candidates that are currently used to treat <a href=\"https:\/\/www.sciencealert.com\/cancer\" rel=\"nofollow\" target=\"_self\">cancer<\/a>.<\/p>\n<p>Already approved by regulators in the US \u2013 meaning potential <a href=\"https:\/\/www.sciencealert.com\/clinical-trials\" rel=\"nofollow\" target=\"_self\">clinical trials<\/a> for Alzheimer\u2019s could start sooner \u2013 the drugs are <a href=\"https:\/\/en.wikipedia.org\/wiki\/Letrozole\">letrozole<\/a> (usually used to treat breast cancer) and <a href=\"https:\/\/en.wikipedia.org\/wiki\/Irinotecan\">irinotecan<\/a> (usually used to treat colon and lung cancer).<\/p>\n<p>Researchers from the University of California, San Francisco (UCSF) and Gladstone Institutes started by looking at how Alzheimer\u2019s altered <a href=\"https:\/\/en.wikipedia.org\/wiki\/Gene_expression\">gene expression<\/a> in the brain.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>In efforts to beat Alzheimer\u2019s disease, researchers are looking at existing drugs that could tackle the condition, and a new study identifies two promising candidates that are currently used to treat cancer. Already approved by regulators in the US \u2013 meaning potential clinical trials for Alzheimer\u2019s could start sooner \u2013 the drugs are letrozole (usually [\u2026]<\/p>\n","protected":false},"author":359,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,47],"tags":[],"class_list":["post-218790","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/218790","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/359"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=218790"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/218790\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=218790"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=218790"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=218790"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}