{"id":218435,"date":"2025-07-22T00:06:04","date_gmt":"2025-07-22T05:06:04","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/07\/apoe-%ce%b54-variant-reveals-hidden-risk-factors-beyond-alzheimers"},"modified":"2025-07-22T00:06:04","modified_gmt":"2025-07-22T05:06:04","slug":"apoe-%ce%b54-variant-reveals-hidden-risk-factors-beyond-alzheimers","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/07\/apoe-%ce%b54-variant-reveals-hidden-risk-factors-beyond-alzheimers","title":{"rendered":"APOE \u03b54 variant reveals hidden risk factors beyond Alzheimer\u2019s"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/apoe-ceb54-variant-reveals-hidden-risk-factors-beyond-alzheimers2.jpg\"><\/a><\/p>\n<p>Further analysis for immune-specific processes revealed <em>APOE \u03b54<\/em> enrichment in various infection-related pathways, including herpes, influenza A, hepatitis, measles, and Epstein-Barr virus (EBV). Significant enrichment was also observed for B-cell, T-cell, and inflammatory signaling cascades. Next, immune cell subtype enrichment analysis revealed the most <em>APOE \u03b54<\/em> enrichment in intermediate and non-classical monocytes among innate immune cells.<\/p>\n<p>Among adaptive immune cells, memory cluster of differentiation 8 (CD8) <a href=\"https:\/\/www.news-medical.net\/health\/What-are-T-Cells.aspx\">T cells<\/a>, regulatory T (Treg) cells, and memory CD4 T cells were the most enriched. Besides, \u03b3\u03b4 T cells and natural killer (NK) cells showed <em>APOE \u03b54<\/em> enrichment. In the liver, a cell-type-specific enrichment analysis revealed the most <em>APOE \u03b54<\/em> enrichment in Kupffer cells and hepatocytes.<\/p>\n<p>Next, the researchers examined whether <em>APOE \u03b54<\/em> CSF proteome changes were reflected in the plasma and used the GNPC dataset for plasma proteome profiling of AD, PDD, FTD, PD, ALS, and non-impaired controls. Fifty-eight plasma proteins associated with the <em>APOE<\/em> genotype were identified in non-impaired controls. CART modeling revealed that these 58 proteins could strongly differentiate between <em>APOE \u03b54<\/em> carriers and non-carriers across neurodegenerative diseases, and this signature was found to be consistent across different sexes and racial groups.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Further analysis for immune-specific processes revealed APOE \u03b54 enrichment in various infection-related pathways, including herpes, influenza A, hepatitis, measles, and Epstein-Barr virus (EBV). Significant enrichment was also observed for B-cell, T-cell, and inflammatory signaling cascades. Next, immune cell subtype enrichment analysis revealed the most APOE \u03b54 enrichment in intermediate and non-classical monocytes among innate immune [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,47],"tags":[],"class_list":["post-218435","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/218435","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=218435"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/218435\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=218435"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=218435"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=218435"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}