{"id":218163,"date":"2025-07-17T14:18:48","date_gmt":"2025-07-17T19:18:48","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/07\/researchers-develop-novel-antibody-rna-therapy-for-resistant-cancers"},"modified":"2025-07-17T14:18:48","modified_gmt":"2025-07-17T19:18:48","slug":"researchers-develop-novel-antibody-rna-therapy-for-resistant-cancers","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/07\/researchers-develop-novel-antibody-rna-therapy-for-resistant-cancers","title":{"rendered":"Researchers develop novel antibody-RNA therapy for resistant cancers"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/researchers-develop-novel-antibody-rna-therapy-for-resistant-cancers2.jpg\"><\/a><\/p>\n<p>A specially engineered antibody that can accurately deliver RNA treatments into hard-to-reach and hard-to-treat tumors significantly improved survival and reduced tumor sizes in animal models, according to a study <a href=\"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.adk1868\" target=\"_blank\">reported<\/a> in Science Translational Medicine.<\/p>\n<p>The study provides evidence that, once injected into the bloodstream, the antibody TMAB3, combined with a type of RNA that stimulates an innate immune reaction, can localize to tumors and penetrate and destroy stubborn diseased cells in pancreatic, brain, and <a href=\"https:\/\/medicalxpress.com\/tags\/skin+cancers\/\" rel=\"tag\" class=\"\">skin cancers<\/a>.<\/p>\n<p>\u201cDelivery of RNA-based therapies to tumors has been a challenge. Our finding that TMAB3 can form antibody\/RNA complexes capable of delivering RNA payloads to tumors provides a new approach to overcome this challenge,\u201d says Peter Glazer, senior author and Robert E. Hunter Professor of Therapeutic Radiology and Genetics at Yale School of Medicine (YSM).<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A specially engineered antibody that can accurately deliver RNA treatments into hard-to-reach and hard-to-treat tumors significantly improved survival and reduced tumor sizes in animal models, according to a study reported in Science Translational Medicine. The study provides evidence that, once injected into the bloodstream, the antibody TMAB3, combined with a type of RNA that stimulates [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1902,11,412,47],"tags":[],"class_list":["post-218163","post","type-post","status-publish","format-standard","hentry","category-bioengineering","category-biotech-medical","category-genetics","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/218163","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=218163"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/218163\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=218163"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=218163"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=218163"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}