{"id":218086,"date":"2025-07-16T22:03:15","date_gmt":"2025-07-17T03:03:15","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/07\/microneedle-based-integrated-pharmacokinetic-and-pharmacodynamic-evaluation-platform-for-personalized-medicine"},"modified":"2025-07-16T22:03:15","modified_gmt":"2025-07-17T03:03:15","slug":"microneedle-based-integrated-pharmacokinetic-and-pharmacodynamic-evaluation-platform-for-personalized-medicine","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/07\/microneedle-based-integrated-pharmacokinetic-and-pharmacodynamic-evaluation-platform-for-personalized-medicine","title":{"rendered":"Microneedle-based integrated pharmacokinetic and pharmacodynamic evaluation platform for personalized medicine"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/microneedle-based-integrated-pharmacokinetic-and-pharmacodynamic-evaluation-platform-for-personalized-medicine.jpg\"><\/a><\/p>\n<p>Precision and personalized medicine for disease management necessitates real-time, continuous monitoring of biomarkers and therapeutic drugs to adjust treatment regimens based on individual patient responses. This study introduces a wearable Microneedle-based Continuous Biomarker\/Drug Monitoring (MCBM) system, designed for the simultaneous, in vivo pharmacokinetic and pharmacodynamic evaluation for diabetes. Utilizing a dual-sensor microneedle and a layer-by-layer nanoenzyme immobilization strategy, the MCBM system achieves high sensitivity and specificity in measuring glucose and metformin concentrations in skin interstitial fluid (ISF). Seamless integration with a smartphone application enables real-time data analysis and feedback, fostering a pharmacologically informed approach to diabetes management. The MCBM system\u2019s validation and in vivo trials demonstrate its precise monitoring of glucose and metformin, offering a tool for personalized treatment adjustments. Its proven biocompatibility and safety suit long-term usage. This system advances personalized diabetes care, highlighting the move towards wearables that adjust drug dosages in real-time, enhancing precision and personalized medicine.<\/p>\n<hr>\n<p>Real-time monitoring of drugs and biomarkers is essential for personalized diabetes care. Here, the authors present a wearable microneedle sensor system enabling simultaneous in vivo monitoring of glucose and metformin in interstitial fluids for personalized medicine.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Precision and personalized medicine for disease management necessitates real-time, continuous monitoring of biomarkers and therapeutic drugs to adjust treatment regimens based on individual patient responses. This study introduces a wearable Microneedle-based Continuous Biomarker\/Drug Monitoring (MCBM) system, designed for the simultaneous, in vivo pharmacokinetic and pharmacodynamic evaluation for diabetes. Utilizing a dual-sensor microneedle and a layer-by-layer [\u2026]<\/p>\n","protected":false},"author":534,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,1512,1977],"tags":[],"class_list":["post-218086","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-mobile-phones","category-wearables"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/218086","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/534"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=218086"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/218086\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=218086"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=218086"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=218086"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}