{"id":217978,"date":"2025-07-15T21:13:00","date_gmt":"2025-07-16T02:13:00","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/07\/a-novel-galnac-sirna-with-potent-and-durable-antithrombotic-effects"},"modified":"2025-07-15T21:13:00","modified_gmt":"2025-07-16T02:13:00","slug":"a-novel-galnac-sirna-with-potent-and-durable-antithrombotic-effects","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/07\/a-novel-galnac-sirna-with-potent-and-durable-antithrombotic-effects","title":{"rendered":"A Novel GalNAc-siRNA With Potent and Durable Antithrombotic Effects"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/a-novel-galnac-sirna-with-potent-and-durable-antithrombotic-effects2.jpg\"><\/a><\/p>\n<p>In the present study, the GalNAc-siRNA molecule RBD4059 showed promising reduction of FXI activity in preclinical animal models and antithrombotic effects without disrupting hemostasis.<\/p>\n<p>RBD4059 is the first FXI-targeting GalNAc-siRNA molecule to reach the clinical stage of development and is a promising candidate for the development of a safe and efficient antithrombotic drug with high patient compliance.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>In the present study, the GalNAc-siRNA molecule RBD4059 showed promising reduction of FXI activity in preclinical animal models and antithrombotic effects without disrupting hemostasis. RBD4059 is the first FXI-targeting GalNAc-siRNA molecule to reach the clinical stage of development and is a promising candidate for the development of a safe and efficient antithrombotic drug with high [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-217978","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/217978","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=217978"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/217978\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=217978"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=217978"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=217978"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}