{"id":217703,"date":"2025-07-12T09:07:06","date_gmt":"2025-07-12T14:07:06","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/07\/data-mining-uncovers-treasure-trove-of-previously-untouchable-proteins-for-drug-development"},"modified":"2025-07-12T09:07:06","modified_gmt":"2025-07-12T14:07:06","slug":"data-mining-uncovers-treasure-trove-of-previously-untouchable-proteins-for-drug-development","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/07\/data-mining-uncovers-treasure-trove-of-previously-untouchable-proteins-for-drug-development","title":{"rendered":"Data mining uncovers treasure-trove of previously \u2018untouchable\u2019 proteins for drug development"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/data-mining-uncovers-treasure-trove-of-previously-untouchable-proteins-for-drug-development2.jpg\"><\/a><\/p>\n<p>Molecular glues, tiny molecules that connect one protein to another, are promising targets for pharmaceutical research. By linking a disease-related protein to one that triggers a cell\u2019s demolition and recycling pathways, pharmaceutical researchers have been able to develop novel therapies for otherwise drug-resistant diseases.<\/p>\n<p>It was thought, however, that this approach to <a href=\"https:\/\/phys.org\/tags\/drug+development\/\" rel=\"tag\" class=\"\">drug development<\/a> was limited to only those proteins that had a specific surface feature called a beta-hairpin loop motif.<\/p>\n<p>Expanding on this once-narrow discovery space, new research <a href=\"https:\/\/www.science.org\/doi\/10.1126\/science.adt6736\" target=\"_blank\">published<\/a> in the journal <i>Science<\/i> has uncovered a vastly wider array of protein surface features capable of binding with a molecular glue degrader (a pharmaceutical version of a molecular glue molecule). These results may open new pathways for treating diseases by targeting proteins previously thought to be \u2018untouchable\u2019 to drug therapies.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Molecular glues, tiny molecules that connect one protein to another, are promising targets for pharmaceutical research. By linking a disease-related protein to one that triggers a cell\u2019s demolition and recycling pathways, pharmaceutical researchers have been able to develop novel therapies for otherwise drug-resistant diseases. It was thought, however, that this approach to drug development was [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-217703","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/217703","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=217703"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/217703\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=217703"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=217703"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=217703"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}