{"id":217485,"date":"2025-07-09T22:06:41","date_gmt":"2025-07-10T03:06:41","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/07\/novel-ai-method-sheds-light-on-how-enzyme-linked-to-alzheimers-selects-its-targets"},"modified":"2025-07-09T22:06:41","modified_gmt":"2025-07-10T03:06:41","slug":"novel-ai-method-sheds-light-on-how-enzyme-linked-to-alzheimers-selects-its-targets","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/07\/novel-ai-method-sheds-light-on-how-enzyme-linked-to-alzheimers-selects-its-targets","title":{"rendered":"Novel AI method sheds light on how enzyme linked to Alzheimer\u2019s selects its targets"},"content":{"rendered":"<p><\/p>\n<p><iframe style=\"display: block; margin: 0 auto; width: 100%; aspect-ratio: 4\/3; object-fit: contain;\" src=\"https:\/\/www.youtube.com\/embed\/93DiWifRRsM?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; encrypted-media; gyroscope;\n   picture-in-picture\" allowfullscreen><\/iframe><\/p>\n<p>Researchers from DZNE, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen (LMU), and Technical University of Munich (TUM) have found that the enzyme \u201cgamma-secretase\u201d\u2014implicated in Alzheimer\u2019s disease and cancer\u2014selects its reaction partners according to a complex scheme of molecular features.<\/p>\n<p>Their study, published in <a href=\"https:\/\/www.nature.com\/articles\/s41467-025-60638-z\" target=\"_blank\"><i>Nature Communications<\/i><\/a>, introduces a methodology that decodes the enzyme\u2019s recognition logic by bridging biochemistry with explainable artificial intelligence (AI). This novel approach could help to better understand the role of <a href=\"https:\/\/medicalxpress.com\/tags\/gamma-secretase\/\" rel=\"tag\" class=\"\">gamma-secretase<\/a> in diseases and aid drug development.<\/p>\n<p>Gamma-secretase is an enzyme belonging to the category of \u201cproteases\u201d that plays a key role in Alzheimer\u2019s disease and cancer. It occurs in the membrane of numerous cells, including neurons, where\u2014acting like a pair of scissors\u2014it cleaves other membrane-bound proteins.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers from DZNE, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen (LMU), and Technical University of Munich (TUM) have found that the enzyme \u201cgamma-secretase\u201d\u2014implicated in Alzheimer\u2019s disease and cancer\u2014selects its reaction partners according to a complex scheme of molecular features. Their study, published in Nature Communications, introduces a methodology that decodes the enzyme\u2019s recognition logic by bridging biochemistry with explainable artificial [\u2026]<\/p>\n","protected":false},"author":732,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,19,6],"tags":[],"class_list":["post-217485","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-chemistry","category-robotics-ai"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/217485","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/732"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=217485"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/217485\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=217485"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=217485"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=217485"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}