{"id":217403,"date":"2025-07-08T18:03:59","date_gmt":"2025-07-08T23:03:59","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/07\/divide-and-conquer-strategy-with-engineered-ossification-center-organoids-for-rapid-bone-healing-through-developmental-cell-recruitment"},"modified":"2025-07-08T18:03:59","modified_gmt":"2025-07-08T23:03:59","slug":"divide-and-conquer-strategy-with-engineered-ossification-center-organoids-for-rapid-bone-healing-through-developmental-cell-recruitment","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/07\/divide-and-conquer-strategy-with-engineered-ossification-center-organoids-for-rapid-bone-healing-through-developmental-cell-recruitment","title":{"rendered":"Divide-and-conquer strategy with engineered ossification center organoids for rapid bone healing through developmental cell recruitment"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/divide-and-conquer-strategy-with-engineered-ossification-center-organoids-for-rapid-bone-healing-through-developmental-cell-recruitment2.jpg\"><\/a><\/p>\n<p>Critical-sized bone defects are a clinical challenge, with long-term recovery often leading to delayed union or nonunion. Here, Zhang <i>et al.<\/i> report an engineered ossification center-like organoid which recruits Krt8+ skeletal stem cells and reduces Has1+ fibrotic cells, mimicking developmental bone formation for regeneration of critical-sized bone defects.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Critical-sized bone defects are a clinical challenge, with long-term recovery often leading to delayed union or nonunion. Here, Zhang et al. report an engineered ossification center-like organoid which recruits Krt8+ skeletal stem cells and reduces Has1+ fibrotic cells, mimicking developmental bone formation for regeneration of critical-sized bone defects.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-217403","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/217403","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=217403"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/217403\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=217403"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=217403"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=217403"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}