{"id":216962,"date":"2025-07-01T17:04:12","date_gmt":"2025-07-01T22:04:12","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/07\/scientists-discover-off-switch-enzyme-that-could-stop-heart-disease-and-diabetes"},"modified":"2025-07-01T17:04:12","modified_gmt":"2025-07-01T22:04:12","slug":"scientists-discover-off-switch-enzyme-that-could-stop-heart-disease-and-diabetes","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/07\/scientists-discover-off-switch-enzyme-that-could-stop-heart-disease-and-diabetes","title":{"rendered":"Scientists discover \u2018off switch\u2019 enzyme that could stop heart disease and diabetes"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/scientists-discover-off-switch-enzyme-that-could-stop-heart-disease-and-diabetes2.webp\"><\/a><\/p>\n<p>Researchers at UT Arlington have discovered a key enzyme, IDO1, that when blocked, helps immune cells regain their ability to properly process cholesterol\u2014something that breaks down during inflammation. This breakthrough could offer a powerful new way to fight heart disease, diabetes, cancer, and more. By \u201cturning off\u201d this enzyme, the team restored cholesterol absorption in macrophages, potentially stopping disease at the source. Even more promising, they found a second enzyme, NOS, that makes things worse\u2014raising hopes that targeting both could pave the way for transformative treatments for millions suffering from inflammation-driven conditions.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers at UT Arlington have discovered a key enzyme, IDO1, that when blocked, helps immune cells regain their ability to properly process cholesterol\u2014something that breaks down during inflammation. This breakthrough could offer a powerful new way to fight heart disease, diabetes, cancer, and more. By \u201cturning off\u201d this enzyme, the team restored cholesterol absorption in [\u2026]<\/p>\n","protected":false},"author":396,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,1522],"tags":[],"class_list":["post-216962","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-innovation"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/216962","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/396"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=216962"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/216962\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=216962"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=216962"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=216962"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}