{"id":216944,"date":"2025-07-01T09:06:01","date_gmt":"2025-07-01T14:06:01","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/07\/engineered-protein-can-turn-off-tissue-damaging-immune-cells-in-autoimmune-diseases"},"modified":"2025-07-01T09:06:01","modified_gmt":"2025-07-01T14:06:01","slug":"engineered-protein-can-turn-off-tissue-damaging-immune-cells-in-autoimmune-diseases","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/07\/engineered-protein-can-turn-off-tissue-damaging-immune-cells-in-autoimmune-diseases","title":{"rendered":"Engineered protein can turn off tissue-damaging immune cells in autoimmune diseases"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/engineered-protein-can-turn-off-tissue-damaging-immune-cells-in-autoimmune-diseases.jpg\"><\/a><\/p>\n<p>An engineered protein turns off the kind of immune cells most likely to damage tissue as part of type-1 diabetes, hepatitis, multiple sclerosis, shows a new study in mice.<\/p>\n<p>In these autoimmune diseases, T cells mistakenly target the body\u2019s own tissues instead of invading viruses or bacteria as they would during normal immune responses. Treatments focused on T cells have been elusive because blocking their action broadly weakens the immune system and creates risk for infections and cancer.<\/p>\n<p><a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(25)00638-5\" target=\"_blank\">Published<\/a> online June 30 in the journal <i>Cell<\/i>, the study revealed that holding closely together two protein groups (signaling complexes) on T cells, including one found more often on T cells involved in autoimmune disease, shuts down those T cells in a limited way.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>An engineered protein turns off the kind of immune cells most likely to damage tissue as part of type-1 diabetes, hepatitis, multiple sclerosis, shows a new study in mice. In these autoimmune diseases, T cells mistakenly target the body\u2019s own tissues instead of invading viruses or bacteria as they would during normal immune responses. Treatments [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1902,11,47],"tags":[],"class_list":["post-216944","post","type-post","status-publish","format-standard","hentry","category-bioengineering","category-biotech-medical","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/216944","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=216944"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/216944\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=216944"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=216944"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=216944"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}