{"id":216897,"date":"2025-06-30T18:06:27","date_gmt":"2025-06-30T23:06:27","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/06\/parkinsons-drug-reduces-symptoms-in-treatment-resistant-depression-clinical-trial-finds"},"modified":"2025-06-30T18:06:27","modified_gmt":"2025-06-30T23:06:27","slug":"parkinsons-drug-reduces-symptoms-in-treatment-resistant-depression-clinical-trial-finds","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/06\/parkinsons-drug-reduces-symptoms-in-treatment-resistant-depression-clinical-trial-finds","title":{"rendered":"Parkinson\u2019s drug reduces symptoms in treatment-resistant depression, clinical trial finds"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/parkinsons-drug-reduces-symptoms-in-treatment-resistant-depression-clinical-trial-finds.jpg\"><\/a><\/p>\n<p>A drug used for Parkinson\u2019s disease has been shown to be effective in reducing the symptoms of difficult to treat depression, according to a study led by the University of Oxford.<\/p>\n<p>In the largest clinical trial to date, pramipexole was found to be substantially more effective than a placebo at reducing the symptoms of <a href=\"https:\/\/medicalxpress.com\/tags\/treatment+resistant+depression\/\" rel=\"tag\" class=\"\">treatment-resistant depression<\/a> (TRD) over the course of nearly a year, when added to ongoing antidepressant medication.<\/p>\n<p>The trial, <a href=\"https:\/\/www.thelancet.com\/journals\/lanpsy\/article\/PIIS2215-0366(25)00194-4\/fulltext\" target=\"_blank\">published<\/a> in <i><i>The Lancet Psychiatry<\/i>,<\/i> included 150 patients with treatment-resistant depression, with equal numbers receiving 48 weeks of pramipexole or a placebo, alongside ongoing antidepressant medication.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A drug used for Parkinson\u2019s disease has been shown to be effective in reducing the symptoms of difficult to treat depression, according to a study led by the University of Oxford. In the largest clinical trial to date, pramipexole was found to be substantially more effective than a placebo at reducing the symptoms of treatment-resistant [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,47],"tags":[],"class_list":["post-216897","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/216897","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=216897"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/216897\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=216897"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=216897"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=216897"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}