{"id":216794,"date":"2025-06-28T14:05:02","date_gmt":"2025-06-28T19:05:02","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/06\/new-human-multi-zonal-liver-organoids-improve-injury-survival-in-rodents"},"modified":"2025-06-28T14:05:02","modified_gmt":"2025-06-28T19:05:02","slug":"new-human-multi-zonal-liver-organoids-improve-injury-survival-in-rodents","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/06\/new-human-multi-zonal-liver-organoids-improve-injury-survival-in-rodents","title":{"rendered":"New human \u2018multi-zonal\u2019 liver organoids improve injury survival in rodents"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/new-human-multi-zonal-liver-organoids-improve-injury-survival-in-rodents.jpg\"><\/a><\/p>\n<p>One reason why our livers excel at clearing waste from our blood system is that the organ functions according to three key \u201czones\u201d that perform specific major tasks. So, if scientists hope to create self-growing patches of liver organoid tissue that could help repair damaged organs, it\u2019s important that the lab-grown tissue faithfully reproduce such zones.<\/p>\n<p>In a groundbreaking paper <a href=\"https:\/\/www.nature.com\/articles\/s41586-025-08850-1\" target=\"_blank\">published<\/a> April 16, 2025<i><i>Nature<\/i>,<\/i> a team of organoid medicine experts at Cincinnati Children\u2019s reports achieving just such a milestone\u2014made from <a href=\"https:\/\/medicalxpress.com\/tags\/human+stem+cells\/\" rel=\"tag\" class=\"\">human stem cells<\/a>. When these humanized organoids were transplanted into rodents whose own liver-bile duct system had been disconnected, the improved organoids nearly doubled the rodents\u2019 survival rate.<\/p>\n<p>\u201cThe research community has long needed a better model for studying human liver biology and disease, because there are outstanding hepatocyte diversity and associated functional orchestrations in the human liver that do not exist in rodents,\u201d says Takanori Takebe, MD, Ph.D., the study\u2019s corresponding author. \u201cThis new system paves the way for studying, and eventually treating, a wide range of otherwise fatal liver disorders.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"<p>One reason why our livers excel at clearing waste from our blood system is that the organ functions according to three key \u201czones\u201d that perform specific major tasks. So, if scientists hope to create self-growing patches of liver organoid tissue that could help repair damaged organs, it\u2019s important that the lab-grown tissue faithfully reproduce such [\u2026]<\/p>\n","protected":false},"author":661,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-216794","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/216794","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/661"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=216794"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/216794\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=216794"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=216794"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=216794"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}