{"id":216548,"date":"2025-06-24T22:13:34","date_gmt":"2025-06-25T03:13:34","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/06\/als-on-a-chip-model-reveals-altered-motor-neuron-signaling"},"modified":"2025-06-24T22:13:34","modified_gmt":"2025-06-25T03:13:34","slug":"als-on-a-chip-model-reveals-altered-motor-neuron-signaling","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/06\/als-on-a-chip-model-reveals-altered-motor-neuron-signaling","title":{"rendered":"\u2018ALS on a chip\u2019 model reveals altered motor neuron signaling"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/als-on-a-chip-model-reveals-altered-motor-neuron-signaling.jpg\"><\/a><\/p>\n<p>Using stem cells from patients with ALS (amyotrophic lateral sclerosis), Cedars-Sinai has created a lifelike model of the mysterious and fatal disease that could help identify a cause of the illness as well as effective treatments.<\/p>\n<p>In a study <a href=\"https:\/\/www.cell.com\/cell-stem-cell\/fulltext\/S1934-5909(25)00222-X\" target=\"_blank\">published<\/a> in the journal <i><i>Cell Stem Cell<\/i>,<\/i> investigators detail how they created \u201cALS on a chip\u201d and the clues the specialized laboratory chip has already produced about nongenetic causes of the disease, also known as Lou Gehrig\u2019s disease.<\/p>\n<p>The work builds on <a href=\"https:\/\/medicalxpress.com\/news\/2023-02-large-scale-generation-muscle-controlling-nerve-cells.html\">previous studies<\/a> where adult cells from ALS patients were reverted into <a href=\"https:\/\/medicalxpress.com\/tags\/stem+cells\/\" rel=\"tag\" class=\"\">stem cells<\/a>. The cells were then pushed forward to produce motor neurons, which die in the disease, causing progressive loss of the ability to move, speak, eat and breathe.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Using stem cells from patients with ALS (amyotrophic lateral sclerosis), Cedars-Sinai has created a lifelike model of the mysterious and fatal disease that could help identify a cause of the illness as well as effective treatments. In a study published in the journal Cell Stem Cell, investigators detail how they created \u201cALS on a chip\u201d [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,1523,412,47],"tags":[],"class_list":["post-216548","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-computing","category-genetics","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/216548","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=216548"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/216548\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=216548"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=216548"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=216548"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}