{"id":216433,"date":"2025-06-22T22:06:40","date_gmt":"2025-06-23T03:06:40","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/06\/exercise-induced-clcf1-attenuates-age-related-muscle-and-bone-decline-in-mice"},"modified":"2025-06-22T22:06:40","modified_gmt":"2025-06-23T03:06:40","slug":"exercise-induced-clcf1-attenuates-age-related-muscle-and-bone-decline-in-mice","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/06\/exercise-induced-clcf1-attenuates-age-related-muscle-and-bone-decline-in-mice","title":{"rendered":"Exercise-induced CLCF1 attenuates age-related muscle and bone decline in mice"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/exercise-induced-clcf1-attenuates-age-related-muscle-and-bone-decline-in-mice.jpg\"><\/a><\/p>\n<p>Aging impairs muscle and bone health, and exercise is known to mitigate this decline, partly through secreted factors. Here, the authors show that the muscle-derived factor CLCF1, which declines with age but is restored by exercise, mediates musculoskeletal benefits in aged mice.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Aging impairs muscle and bone health, and exercise is known to mitigate this decline, partly through secreted factors. Here, the authors show that the muscle-derived factor CLCF1, which declines with age but is restored by exercise, mediates musculoskeletal benefits in aged mice.<\/p>\n","protected":false},"author":709,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[269],"tags":[],"class_list":["post-216433","post","type-post","status-publish","format-standard","hentry","category-life-extension"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/216433","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/709"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=216433"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/216433\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=216433"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=216433"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=216433"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}