{"id":216109,"date":"2025-06-17T06:19:42","date_gmt":"2025-06-17T11:19:42","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/06\/glial-replacement-therapy-slows-huntingtons-disease-in-adult-mice"},"modified":"2025-06-17T06:19:42","modified_gmt":"2025-06-17T11:19:42","slug":"glial-replacement-therapy-slows-huntingtons-disease-in-adult-mice","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/06\/glial-replacement-therapy-slows-huntingtons-disease-in-adult-mice","title":{"rendered":"Glial replacement therapy slows Huntington\u2019s disease in adult mice"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/glial-replacement-therapy-slows-huntingtons-disease-in-adult-mice2.jpg\"><\/a><\/p>\n<p>Huntington\u2019s disease has long defied attempts to rescue suffering neurons. A new study in <a href=\"https:\/\/doi.org\/10.1016\/j.celrep.2025.115762\" target=\"_blank\"><i><i>Cell Reports<\/i><\/a><\/i> shows that transplanting healthy human glial progenitor cells into the brains of adult animal models of the disease not only slowed motor and cognitive decline but also extended lifespan. These findings shift our understanding of Huntington\u2019s pathology and open a potential path to cell-based therapies in adults already showing symptoms.<\/p>\n<p>\u201cGlia are essential caretakers of neurons,\u201d said Steve Goldman, MD, Ph.D., co-director of the University of Rochester Center for Translational Neuromedicine and lead author of the study.<\/p>\n<p>\u201cThe restoration of healthy glial support\u2014even after symptoms begin\u2014could reset neuronal gene expression, stabilize synaptic function, and meaningfully delay disease progression. This study shifts the perspective on Huntington\u2019s from a neuron-centric view to one that shows a critical role for glial pathology in driving synaptic dysfunction. It also tells us that the adult brain still has the capacity for repair when you target the right cells.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Huntington\u2019s disease has long defied attempts to rescue suffering neurons. A new study in Cell Reports shows that transplanting healthy human glial progenitor cells into the brains of adult animal models of the disease not only slowed motor and cognitive decline but also extended lifespan. These findings shift our understanding of Huntington\u2019s pathology and open [\u2026]<\/p>\n","protected":false},"author":427,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,47],"tags":[],"class_list":["post-216109","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/216109","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/427"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=216109"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/216109\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=216109"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=216109"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=216109"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}