{"id":216024,"date":"2025-06-16T14:05:43","date_gmt":"2025-06-16T19:05:43","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/06\/newly-discovered-mechanism-of-mitochondrial-dysfunction-in-obesity-may-drive-insulin-resistance-and-type-2-diabetes"},"modified":"2025-06-16T14:05:43","modified_gmt":"2025-06-16T19:05:43","slug":"newly-discovered-mechanism-of-mitochondrial-dysfunction-in-obesity-may-drive-insulin-resistance-and-type-2-diabetes","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/06\/newly-discovered-mechanism-of-mitochondrial-dysfunction-in-obesity-may-drive-insulin-resistance-and-type-2-diabetes","title":{"rendered":"Newly discovered mechanism of mitochondrial dysfunction in obesity may drive insulin resistance and type 2 diabetes"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/newly-discovered-mechanism-of-mitochondrial-dysfunction-in-obesity-may-drive-insulin-resistance-and-type-2-diabetes.jpg\"><\/a><\/p>\n<p>A newly discovered mechanism that leads to liver dysfunction may be a key factor in type 2 diabetes and other metabolic disorders in individuals with obesity, according to a new study led by Harvard T.H. Chan School of Public Health.<\/p>\n<p>The dysfunction identified\u2014dysregulated hepatic coenzyme Q metabolism\u2014leads to excessive reactive oxygen species (ROS) produced by mitochondria at a single specific site in an enzyme called complex I. The researchers say the discovery offers a potential path for new, precise treatments for metabolic diseases.<\/p>\n<p>\u201cOur findings provide the first step toward solving a complex problem in the field of metabolic disease research that has stood for three decades,\u201d said corresponding author G\u00f6khan S. Hotamisligil, James Stevens Simmons Professor of Genetics and Metabolism.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A newly discovered mechanism that leads to liver dysfunction may be a key factor in type 2 diabetes and other metabolic disorders in individuals with obesity, according to a new study led by Harvard T.H. Chan School of Public Health. The dysfunction identified\u2014dysregulated hepatic coenzyme Q metabolism\u2014leads to excessive reactive oxygen species (ROS) produced by [\u2026]<\/p>\n","protected":false},"author":707,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412,1495],"tags":[],"class_list":["post-216024","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics","category-health"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/216024","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/707"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=216024"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/216024\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=216024"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=216024"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=216024"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}