{"id":215995,"date":"2025-06-16T09:09:02","date_gmt":"2025-06-16T14:09:02","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/06\/evolutionary-model-for-antibiotic-resistance-reveals-dose-timing-critical-to-care"},"modified":"2025-06-16T09:09:02","modified_gmt":"2025-06-16T14:09:02","slug":"evolutionary-model-for-antibiotic-resistance-reveals-dose-timing-critical-to-care","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/06\/evolutionary-model-for-antibiotic-resistance-reveals-dose-timing-critical-to-care","title":{"rendered":"Evolutionary model for antibiotic resistance reveals dose timing critical to care"},"content":{"rendered":"

<\/a><\/p>\n

Cleveland Clinic researchers are working to improve the way we use evolutionary modeling to understand drug resistance. The study, published in Science Advances<\/i><\/a>, uses a new type of evolutionary model called a \u201cfitness seascape\u201d to incorporate a patient\u2019s dosage schedule into models that predict whether an infection will develop antibiotic resistance, and has found that inconsistent timing and missing early doses can lead to treatment failure.<\/p>\n

A team led by Jacob Scott, MD, DPhil., including study first author Eshan King, an MD\/Ph. D. student at Case Western Reserve University School of Medicine, is refining models that determine recommended antibiotic doses by incorporating bacterial evolutionary dynamics.<\/p>\n

\u201cWith the rise of \u2018superbugs,\u2019 or antibiotic-resistant bacterial infections<\/a>, the world is reaching a crisis point<\/a>,\u201d says Dr. Scott, the study\u2019s senior author. \u201cWe\u2019ve already seen from MRSA what can happen if a bacterium becomes antibiotic-resistant. We need to address the problem before it impacts our ability to use antibiotics in more routine aspects of medical care, like surgery or childbirth.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"

Cleveland Clinic researchers are working to improve the way we use evolutionary modeling to understand drug resistance. The study, published in Science Advances, uses a new type of evolutionary model called a \u201cfitness seascape\u201d to incorporate a patient\u2019s dosage schedule into models that predict whether an infection will develop antibiotic resistance, and has found that [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-215995","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/215995","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=215995"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/215995\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=215995"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=215995"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=215995"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}