{"id":215888,"date":"2025-06-14T02:07:44","date_gmt":"2025-06-14T07:07:44","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/06\/repurposed-cancer-drugs-shown-to-promote-stroke-recovery-and-limit-brain-damage"},"modified":"2025-06-14T02:07:44","modified_gmt":"2025-06-14T07:07:44","slug":"repurposed-cancer-drugs-shown-to-promote-stroke-recovery-and-limit-brain-damage","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/06\/repurposed-cancer-drugs-shown-to-promote-stroke-recovery-and-limit-brain-damage","title":{"rendered":"Repurposed cancer drugs shown to promote stroke recovery and limit brain damage"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/repurposed-cancer-drugs-shown-to-promote-stroke-recovery-and-limit-brain-damage.jpg\"><\/a><\/p>\n<p>Stroke remains one of the leading causes of death, disability, increased economic burden and decreased quality of life around the world. Current stroke therapies are time-limited and largely focused on restoring blood flow, and there are few which address the secondary wave of inflammation that causes further injury in the hours and days after stroke.<\/p>\n<p>A study by researchers from the Yong Loo Lin School of Medicine, National University of Singapore (NUS Medicine), has shown that a class of drugs, HDACi (<a href=\"https:\/\/medicalxpress.com\/tags\/histone+deacetylase+inhibitors\/\" rel=\"tag\" class=\"\">histone deacetylase inhibitors<\/a>), protects neurons and limits <a href=\"https:\/\/medicalxpress.com\/tags\/brain+damage\/\" rel=\"tag\" class=\"\">brain damage<\/a> following stroke by altering the gene expression of microglia, the immune cells of the brain.<\/p>\n<p>HDACi are currently used or being tested as treatments for certain cancers and are also being researched for neurological conditions such as Alzheimer\u2019s disease.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Stroke remains one of the leading causes of death, disability, increased economic burden and decreased quality of life around the world. Current stroke therapies are time-limited and largely focused on restoring blood flow, and there are few which address the secondary wave of inflammation that causes further injury in the hours and days after stroke. [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,47],"tags":[],"class_list":["post-215888","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/215888","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=215888"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/215888\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=215888"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=215888"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=215888"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}