{"id":215708,"date":"2025-06-10T14:09:39","date_gmt":"2025-06-10T19:09:39","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/06\/serotonin-transporter-inhibits-antitumor-immunity-through-regulating-the-intratumoral-serotonin-axis"},"modified":"2025-06-10T14:09:39","modified_gmt":"2025-06-10T19:09:39","slug":"serotonin-transporter-inhibits-antitumor-immunity-through-regulating-the-intratumoral-serotonin-axis","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/06\/serotonin-transporter-inhibits-antitumor-immunity-through-regulating-the-intratumoral-serotonin-axis","title":{"rendered":"Serotonin transporter inhibits antitumor immunity through regulating the intratumoral serotonin axis"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/serotonin-transporter-inhibits-antitumor-immunity-through-regulating-the-intratumoral-serotonin-axis2.jpg\"><\/a><\/p>\n<p>Serotonin signaling and gut-immune crosstalk: the microbiome\u2019s role in antitumor immunity.<\/p>\n<p>\u201c\u2026Serotonin transporter inhibits cytotoxic CD8-positive T lymphocyte antitumor immunity by depleting serotonin within the tumor microenvironment\u2026\u201d<\/p>\n<p>\u201c\u2026Serotonin transporter-blocking selective serotonin reuptake inhibitor antidepressants enhance cytotoxic CD8-positive T lymphocyte antitumor immunity and act synergistically with programmed cell death protein 1 immune checkpoint blockade therapy\u2026\u201d<\/p>\n<p>To this end, here\u2026<\/p>\n<p>\u201c\u2026Tumor-infiltrating cytotoxic CD8-positive T lymphocytes were identified as the primary producers and mediators of a local, immunomodulatory serotonin signaling pathway independent of the gastrointestinal tract\u2026\u201d<\/p>\n<p>\u201c\u2026Upon recognition of tumor antigens, tumor-infiltrating cytotoxic CD8-positive T lymphocytes upregulate tryptophan hydroxylase 1, which synthesizes serotonin followed by its release into the tumor microenvironment to enhance T lymphocyte activation via serotonin signaling\u2026\u201d<\/p>\n<p>In short\u2026<\/p>\n<div class=\"more-link-wrapper\"> <a class=\"more-link\" href=\"https:\/\/lifeboat.com\/blog\/2025\/06\/serotonin-transporter-inhibits-antitumor-immunity-through-regulating-the-intratumoral-serotonin-axis\">Continue reading \u201cSerotonin transporter inhibits antitumor immunity through regulating the intratumoral serotonin axis\u201d | &gt;<\/a><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Serotonin signaling and gut-immune crosstalk: the microbiome\u2019s role in antitumor immunity. \u201c\u2026Serotonin transporter inhibits cytotoxic CD8-positive T lymphocyte antitumor immunity by depleting serotonin within the tumor microenvironment\u2026\u201d \u201c\u2026Serotonin transporter-blocking selective serotonin reuptake inhibitor antidepressants enhance cytotoxic CD8-positive T lymphocyte antitumor immunity and act synergistically with programmed cell death protein 1 immune checkpoint blockade therapy\u2026\u201d To [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,269],"tags":[],"class_list":["post-215708","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-life-extension"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/215708","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=215708"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/215708\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=215708"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=215708"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=215708"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}