{"id":215640,"date":"2025-06-08T21:11:19","date_gmt":"2025-06-09T02:11:19","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/06\/the-nlrp3-inflammasome-in-microglia-regulates-repetitive-behavior-by-modulating-nmda-glutamate-receptor-functions"},"modified":"2025-06-08T21:11:19","modified_gmt":"2025-06-09T02:11:19","slug":"the-nlrp3-inflammasome-in-microglia-regulates-repetitive-behavior-by-modulating-nmda-glutamate-receptor-functions","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/06\/the-nlrp3-inflammasome-in-microglia-regulates-repetitive-behavior-by-modulating-nmda-glutamate-receptor-functions","title":{"rendered":"The NLRP3 inflammasome in microglia regulates repetitive behavior by modulating NMDA glutamate receptor functions"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/the-nlrp3-inflammasome-in-microglia-regulates-repetitive-behavior-by-modulating-nmda-glutamate-receptor-functions2.jpg\"><\/a><\/p>\n<p>In this study, Jung et al. investigate the effect of excessive NLRP3-mediated neuroinflammation on synaptic functions and behaviors using Nlrp3D301N-conditional knockin mice. Strikingly, excessive NLRP3-mediated neuroinflammation causes NMDAR hyperactivation, leading to abnormal behaviors. Treatment with IL-1\u03b2 receptor antagonist (IL-1RA) or NMDAR antagonist reverses the pathological phenotypes.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>In this study, Jung et al. investigate the effect of excessive NLRP3-mediated neuroinflammation on synaptic functions and behaviors using Nlrp3D301N-conditional knockin mice. Strikingly, excessive NLRP3-mediated neuroinflammation causes NMDAR hyperactivation, leading to abnormal behaviors. Treatment with IL-1\u03b2 receptor antagonist (IL-1RA) or NMDAR antagonist reverses the pathological phenotypes.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"class_list":["post-215640","post","type-post","status-publish","format-standard","hentry","category-futurism"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/215640","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=215640"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/215640\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=215640"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=215640"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=215640"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}