{"id":215550,"date":"2025-06-06T21:14:54","date_gmt":"2025-06-07T02:14:54","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/06\/sickle-cell-disease-induces-chromatin-introversion-and-ferroptosis-in-cd8-t-cells-to-suppress-anti-tumor-immunity"},"modified":"2025-06-06T21:14:54","modified_gmt":"2025-06-07T02:14:54","slug":"sickle-cell-disease-induces-chromatin-introversion-and-ferroptosis-in-cd8-t-cells-to-suppress-anti-tumor-immunity","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/06\/sickle-cell-disease-induces-chromatin-introversion-and-ferroptosis-in-cd8-t-cells-to-suppress-anti-tumor-immunity","title":{"rendered":"Sickle cell disease induces chromatin introversion and ferroptosis in CD8+ T cells to suppress anti-tumor immunity"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/sickle-cell-disease-induces-chromatin-introversion-and-ferroptosis-in-cd8-t-cells-to-suppress-anti-tumor-immunity2.jpg\"><\/a><\/p>\n<p>How sickle cell disease suppresses antitumor immunity.<\/p>\n<p>Sickle cell disease (SCD) have a higher risk of developing certain cancers than the general population, but the mechanisms driving this increased risk remain unclear.<\/p>\n<p>SCD inhibits CD8+ T cell function in the tumor microenvironment, potentially affecting cancer immunotherapy.<\/p>\n<p>The researchers reveal that SCD alters the 3D genome architecture of CD8+ T cells, triggering ferroptosis and impairing antitumor response resulting in reduced expression of anti-ferroptotic genes, including <i>SLC7A11<\/i> and hydrogen sulfide (H2S) biogenesis genes, thereby increasing susceptibility to ferroptosis.<\/p>\n<p>They also demonstrate that hydrogen sulfide treatment rescued <i>SLC7A11<\/i> expression, mitigated ferroptosis and enhanced immune and anti-tumor responses, thereby offering new avenues for precision immunotherapy in patients with inherited disorders. <a href=\"https:\/\/sciencemission.com\/Sickle-cell-disease\">https:\/\/sciencemission.com\/Sickle-cell-disease<\/a><\/p>\n<hr>\n<p>Sickle cell disease (SCD) inhibits CD8+ T cell function in the tumor microenvironment, potentially affecting cancer immunotherapy. Zhao, Hu, Deng, et al. reveal that SCD alters the 3D genome architecture of CD8+ T cells, triggering ferroptosis and impairing anti-tumor responses, which can be reversed by hydrogen sulfide treatment, offering new avenues for precision immunotherapy in patients with inherited disorders.<\/p>\n<div class=\"more-link-wrapper\"> <a class=\"more-link\" href=\"https:\/\/lifeboat.com\/blog\/2025\/06\/sickle-cell-disease-induces-chromatin-introversion-and-ferroptosis-in-cd8-t-cells-to-suppress-anti-tumor-immunity\">Continue reading \u201cSickle cell disease induces chromatin introversion and ferroptosis in CD8+ T cells to suppress anti-tumor immunity\u201d | &gt;<\/a><\/div><\/p>\n","protected":false},"excerpt":{"rendered":"<p>How sickle cell disease suppresses antitumor immunity. Sickle cell disease (SCD) have a higher risk of developing certain cancers than the general population, but the mechanisms driving this increased risk remain unclear. SCD inhibits CD8+ T cell function in the tumor microenvironment, potentially affecting cancer immunotherapy. The researchers reveal that SCD alters the 3D genome [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-215550","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/215550","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=215550"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/215550\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=215550"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=215550"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=215550"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}